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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
19
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pubmed:dateCreated |
2010-5-12
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pubmed:abstractText |
We report that adrenocorticotropic hormone (ACTH) protects against osteonecrosis of the femoral head induced by depot methylprednisolone acetate (depomedrol). This therapeutic response likely arises from enhanced osteoblastic support and the stimulation of VEGF by ACTH; the latter is largely responsible for maintaining the fine vascular network that surrounds highly remodeling bone. We suggest examining the efficacy of ACTH in preventing human osteonecrosis, a devastating complication of glucocorticoid therapy.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1091-6490
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pubmed:author |
pubmed-author:BlairHarry CHC,
pubmed-author:IqbalJameelJ,
pubmed-author:IsalesCarlosC,
pubmed-author:JosKK,
pubmed-author:LevineAliceA,
pubmed-author:LiJianhuaJ,
pubmed-author:LiuXuanX,
pubmed-author:PengYuanzhenY,
pubmed-author:RobinsonLisa JLJ,
pubmed-author:ShiXingmingX,
pubmed-author:TourkovaIrina LIL,
pubmed-author:VioMM,
pubmed-author:WangYujuanY,
pubmed-author:YangGuozheG,
pubmed-author:YaroslavskiyBeatrice BBB,
pubmed-author:ZaidiMoneM,
pubmed-author:ZhuLing-LingLL
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pubmed:issnType |
Electronic
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pubmed:day |
11
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8782-7
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pubmed:dateRevised |
2010-11-12
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pubmed:meshHeading |
pubmed-meshheading:20421485-3T3 Cells,
pubmed-meshheading:20421485-Adrenocorticotropic Hormone,
pubmed-meshheading:20421485-Animals,
pubmed-meshheading:20421485-Apoptosis,
pubmed-meshheading:20421485-Cell Differentiation,
pubmed-meshheading:20421485-Cytoprotection,
pubmed-meshheading:20421485-Female,
pubmed-meshheading:20421485-Femur,
pubmed-meshheading:20421485-Glucocorticoids,
pubmed-meshheading:20421485-Humans,
pubmed-meshheading:20421485-Mice,
pubmed-meshheading:20421485-Osteoblasts,
pubmed-meshheading:20421485-Osteoclasts,
pubmed-meshheading:20421485-Osteonecrosis,
pubmed-meshheading:20421485-Protective Agents,
pubmed-meshheading:20421485-Rabbits,
pubmed-meshheading:20421485-Vascular Endothelial Growth Factor A
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pubmed:year |
2010
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pubmed:articleTitle |
ACTH protects against glucocorticoid-induced osteonecrosis of bone.
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pubmed:affiliation |
The Mount Sinai Bone Program, Mount Sinai School of Medicine, New York, NY 10029, USA. mone.zaidi@mssm.edu
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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