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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2010-4-29
pubmed:abstractText
Smoking is a leading global cause of disease and mortality. We established the Oxford-GlaxoSmithKline study (Ox-GSK) to perform a genome-wide meta-analysis of SNP association with smoking-related behavioral traits. Our final data set included 41,150 individuals drawn from 20 disease, population and control cohorts. Our analysis confirmed an effect on smoking quantity at a locus on 15q25 (P = 9.45 x 10(-19)) that includes CHRNA5, CHRNA3 and CHRNB4, three genes encoding neuronal nicotinic acetylcholine receptor subunits. We used data from the 1000 Genomes project to investigate the region using imputation, which allowed for analysis of virtually all common SNPs in the region and offered a fivefold increase in marker density over HapMap2 (ref. 2) as an imputation reference panel. Our fine-mapping approach identified a SNP showing the highest significance, rs55853698, located within the promoter region of CHRNA5. Conditional analysis also identified a secondary locus (rs6495308) in CHRNA3.
pubmed:grant
pubmed:commentsCorrections
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
1546-1718
pubmed:author
pubmed-author:MeiselZZ, pubmed-author:AndersonCarl ACA, pubmed-author:AbecasisGonçalo RGR, pubmed-author:CampbellSusanS, pubmed-author:FrancksClydeC, pubmed-author:BerrettiniWadeW, pubmed-author:MathewChristopher GCG, pubmed-author:WarehamNicholas JNJ, pubmed-author:PreisigMartinM, pubmed-author:McGuffinPeterP, pubmed-author:WrightAlan FAF, pubmed-author:WaksmanRonR, pubmed-author:KentKenneth MKM, pubmed-author:PichardAugusto DAD, pubmed-author:KennedyJames LJL, pubmed-author:DahmenNorbertN, pubmed-author:WorthingtonJaneJ, pubmed-author:ThomsonWendyW, pubmed-author:RaderDaniel JDJ, pubmed-author:WaeberGérardG, pubmed-author:SamaniNilesh JNJ, pubmed-author:JohnUlrichU, pubmed-author:SchlessingerDavidD, pubmed-author:VincentJohn BJB, pubmed-author:MugliaPierandreaP, pubmed-author:DayRichardR, pubmed-author:BakkePerP, pubmed-author:GulsvikAmundA, pubmed-author:HorstmannSonjaS, pubmed-author:MooserVincentV, pubmed-author:ZhaoJing HuaJH, pubmed-author:AhmadTariqT, pubmed-author:LoosRuth J FRJ, pubmed-author:VollenweiderPeterP, pubmed-author:BartonAnneA, pubmed-author:DevaneyJoseph MJM, pubmed-author:BarterPhilipP, pubmed-author:CampbellHarryH, pubmed-author:WilsonJames FJF, pubmed-author:ParkesMilesM, pubmed-author:WichmannH-ErichHE, pubmed-author:VölzkeHenryH, pubmed-author:WittigMichaelM, pubmed-author:KhawKay-TeeKT, pubmed-author:BarrosoInêsI, pubmed-author:StraussJohnJ, pubmed-author:McPhersonRuthR, pubmed-author:FarmerAnneA, pubmed-author:FarrallMartinM, pubmed-author:RujescuDanD, pubmed-author:St ClairDavidD, pubmed-author:IsingMarcusM, pubmed-author:BusoneroFabioF, pubmed-author:WilenskyRobertR, pubmed-author:ReillyMuredach PMP, pubmed-author:TerraccianoAntonioA, pubmed-author:SatsangiJackJ, pubmed-author:RudanIgorI, pubmed-author:TozziFedericaF, pubmed-author:BalmforthAnthony JAJ, pubmed-author:ThompsonJohn RJR, pubmed-author:SatlerLowellL, pubmed-author:MunroePatricia BPB, pubmed-author:CaulfieldMarkM, pubmed-author:KoonerJaspalJ, pubmed-author:MatthewsKeithK, pubmed-author:BurnettMary SusanMS, pubmed-author:YuanXinX, pubmed-author:WaterworthDawn MDM, pubmed-author:EpsteinStephenS, pubmed-author:SchäferArneA, pubmed-author:DominiczakAnnaA, pubmed-author:MarchiniJonathanJ, pubmed-author:HallAlistair SAS, pubmed-author:PolasekOzrenO, pubmed-author:RawalRajeshR, pubmed-author:UdaManuelaM, pubmed-author:EyreSteveS, pubmed-author:PetersmannAstridA, pubmed-author:MiddletonLefkosL
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