|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2010-4-23
|
|
pubmed:abstractText |
Stress mobilizes elements from the neuroendocrine system to modulate immune responses. Cholinergic stimulation via nicotinic receptor (nAchR) is a major neuroendocrine signaling axis associated with the stress response whose specific effects on the immune system are unknown. Here, we show that nAchR activation by topical agonist application or deletion of the nAChR antagonist catestatin (Chga(-/-)) reduced antimicrobial peptide (AMP) activity in skin extracts and increased susceptibility to methicillin-resistant Staphylococcus aureus and Group A Streptococcus infections. The adverse effects on AMP expression and infection were rescued by topical application of a nAChR antagonist. Stress-induced nAChR activation increased infection in wild-type, but not Chga(-/-) or cathelicidin-deficient, mice. These data identify a mechanism for the negative regulation of host-innate AMP response to infection through cholinergic activation and indicate nAChR-mediated cathelicidin dysregulation as a potential mechanism for increased susceptibility to infection following prolonged stress or nicotine use.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-10588992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-10666137,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-10784615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-11121511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-11342591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-11442754,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-11719807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-12244054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-12244186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-12469056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-12490958,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-12508119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-12603850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-12782669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-12832959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-1409725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-14707090,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-15675959,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-15854055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-15908937,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-15964896,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-16007257,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-16128625,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-16177355,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-16456005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-16549778,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-16895558,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-16912692,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-17273548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-17276464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-17310278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-17621952,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-17943185,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-17975669,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-18185531,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-18191570,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-18639627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-18829677,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-1901580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-19217824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-19571591,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-19632243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-20413092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-20514672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-2997278,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-3299384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-4390632,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-8114833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-8331294,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-9202117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20413096-9671108
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1934-6069
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
Copyright 2010 Elsevier Inc. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
22
|
|
pubmed:volume |
7
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
277-89
|
|
pubmed:dateRevised |
2011-7-27
|
|
pubmed:meshHeading |
|
