Source:http://linkedlifedata.com/resource/pubmed/id/20412099
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
2011-6-9
|
| pubmed:abstractText |
Renal transplantation is the optimal treatment for pediatric end-stage renal disease. We examined 51 children <20 yr old who underwent a total of 52 living-donor renal transplantations at Osaka University Hospital between 1972 and 2004. The mean age at transplantation was 13.7 (3-19 yr). The mean duration of follow-up was 16.5 yr. The five-, 10-, and 20-yr patient survival rates following renal transplantation were 94%, 90%, and 87%, respectively. The five-, 10-, and 20-yr graft survival rates were 76%, 65%, and 48%, respectively. A double-drug regimen was used before 1987; this was replaced by a triple-drug regimen including a calcineurin inhibitor in 1988. The five-, 10-, and 20-yr graft survival rates after 1988 (89%, 80%, and 60%, respectively) were higher than those before 1987. Growth was examined among patients <15 yr old at the time of surgery, and height standard deviation (SD) scores (Z-scores) were analyzed in 14 patients who displayed favorable renal function after transplantation. At the time of transplantation, mean SD score (SDS) was -2.39, and mean final adult SDS was -1.79. Rates of patient and graft survival after renal transplantation were mostly favorable. Future goals must include overcoming chronic rejection and establishing a steroid discontinuation protocol to improve growth.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
1399-0012
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| pubmed:author | |
| pubmed:copyrightInfo |
© 2010 John Wiley & Sons A/S.
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| pubmed:issnType |
Electronic
|
| pubmed:volume |
25
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
388-94
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| pubmed:meshHeading |
pubmed-meshheading:20412099-Adolescent,
pubmed-meshheading:20412099-Adult,
pubmed-meshheading:20412099-Child,
pubmed-meshheading:20412099-Child, Preschool,
pubmed-meshheading:20412099-Female,
pubmed-meshheading:20412099-Follow-Up Studies,
pubmed-meshheading:20412099-Glomerular Filtration Rate,
pubmed-meshheading:20412099-Graft Rejection,
pubmed-meshheading:20412099-Graft Survival,
pubmed-meshheading:20412099-Humans,
pubmed-meshheading:20412099-Kidney Failure, Chronic,
pubmed-meshheading:20412099-Kidney Function Tests,
pubmed-meshheading:20412099-Kidney Transplantation,
pubmed-meshheading:20412099-Male,
pubmed-meshheading:20412099-Postoperative Complications,
pubmed-meshheading:20412099-Survival Rate,
pubmed-meshheading:20412099-Time Factors,
pubmed-meshheading:20412099-Treatment Outcome,
pubmed-meshheading:20412099-Young Adult
|
| pubmed:year |
2011
|
| pubmed:articleTitle |
Long-term outcome of pediatric renal transplantation: a single center experience.
|
| pubmed:affiliation |
Department of Specific Organ Regulation, Osaka University Graduate School of Medicine, Osaka, Japan.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial
|