|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
2010-4-19
|
|
pubmed:abstractText |
The inflammatory response after prolonged ischemia and subsequent reperfusion leads to increased risk of primary organ dysfunction after cardiac transplantation. It has been demonstrated that the fibrin-derived peptide Bbeta(15-42) (also called FX06) reduces infarct size in coronary artery occlusion/reperfusion models by inhibition of leukocyte migration. Further, Bbeta(15-42) preserves endothelial barrier function. The purpose of this study was to investigate whether Bbeta(15-42) has a protective effect in cardiac allografts exposed to prolonged global ischemia and subsequent in vivo reperfusion.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1534-6080
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
89
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
824-9
|
|
pubmed:meshHeading |
pubmed-meshheading:20405575-Animals,
pubmed-meshheading:20405575-Biological Markers,
pubmed-meshheading:20405575-Cardiac Output,
pubmed-meshheading:20405575-Cardiotonic Agents,
pubmed-meshheading:20405575-Cell Movement,
pubmed-meshheading:20405575-Cold Ischemia,
pubmed-meshheading:20405575-Fibrin Fibrinogen Degradation Products,
pubmed-meshheading:20405575-Heart Transplantation,
pubmed-meshheading:20405575-Leukocytes,
pubmed-meshheading:20405575-Male,
pubmed-meshheading:20405575-Models, Animal,
pubmed-meshheading:20405575-Myocardial Reperfusion Injury,
pubmed-meshheading:20405575-Myocardium,
pubmed-meshheading:20405575-Necrosis,
pubmed-meshheading:20405575-Organ Preservation Solutions,
pubmed-meshheading:20405575-Peptide Fragments,
pubmed-meshheading:20405575-Rats,
pubmed-meshheading:20405575-Rats, Inbred Lew,
pubmed-meshheading:20405575-Time Factors,
pubmed-meshheading:20405575-Transplantation, Homologous,
pubmed-meshheading:20405575-Troponin T,
pubmed-meshheading:20405575-Ventricular Function, Left,
pubmed-meshheading:20405575-Ventricular Pressure
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
The fibrin-derived peptide Bbeta(15-42) significantly attenuates ischemia-reperfusion injury in a cardiac transplant model.
|
|
pubmed:affiliation |
Department of Cardiac Surgery, Innsbruck Medical University, Innsbruck, Austria.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
