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rdf:type |
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lifeskim:mentions |
umls-concept:C0003818,
umls-concept:C0021467,
umls-concept:C0021469,
umls-concept:C0024623,
umls-concept:C0026377,
umls-concept:C0086418,
umls-concept:C0162638,
umls-concept:C0334227,
umls-concept:C0376515,
umls-concept:C0392747,
umls-concept:C1314939,
umls-concept:C1514485
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pubmed:dateCreated |
2010-5-20
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pubmed:abstractText |
Arsenic trioxide has been established as a first-line agent for treating acute promyelocytic leukemia. Experimental data suggest that arsenic trioxide also can have a potential use as chemotherapeutic agent for other malignancies. The precise mechanisms of action of arsenic trioxide have though not been elucidated. As the role of Bcl-2 in arsenic trioxide-mediated cell apoptosis and conformation change of Bcl-2 in response to arsenic trioxide treatment has not been studied. The aim of the present study was to determine whether conformation change of Bcl-2 is involved in the action of arsenic trioxide.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-10639136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-10736809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-11559723,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-11833067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-12124315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-12838300,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-14634621,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-14980220,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-15093545,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-15234563,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-15844663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-15948253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-16007134,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-16019469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-16217749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-16243384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-16243795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-16261844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-16328441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-16569477,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-16904648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-17150035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-17275888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-18297286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-18710422,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-18726487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-18806735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-18949620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-18984268,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-19208092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-19228717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-19465052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-19671798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-19934311,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/20403207-9864170
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1477-7819
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
8
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
31
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:20403207-Annexin A5,
pubmed-meshheading:20403207-Antineoplastic Agents,
pubmed-meshheading:20403207-Apoptosis,
pubmed-meshheading:20403207-Arsenicals,
pubmed-meshheading:20403207-Blotting, Western,
pubmed-meshheading:20403207-Cell Proliferation,
pubmed-meshheading:20403207-Flow Cytometry,
pubmed-meshheading:20403207-Fluorescent Antibody Technique,
pubmed-meshheading:20403207-Humans,
pubmed-meshheading:20403207-Oxides,
pubmed-meshheading:20403207-Protein Conformation,
pubmed-meshheading:20403207-Proto-Oncogene Proteins c-bcl-2,
pubmed-meshheading:20403207-Stomach Neoplasms,
pubmed-meshheading:20403207-Tumor Cells, Cultured,
pubmed-meshheading:20403207-bcl-2-Associated X Protein
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pubmed:year |
2010
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pubmed:articleTitle |
The conformation change of Bcl-2 is involved in arsenic trioxide-induced apoptosis and inhibition of proliferation in SGC7901 human gastric cancer cells.
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pubmed:affiliation |
Department of Surgery, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou 325000, China. zhengyihu@gmail.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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