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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-4-16
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pubmed:abstractText |
The lack of sensitivity of chronic myeloid leukemia (CML) stem cells to imatinib mesylate (IM) commonly leads to drug dose escalation or early disease relapses when therapy is stopped. Here, we report that packaging of IM into a biodegradable carrier based on polyelectrolyte microcapsules increases drug retention and antitumor activity in CML stem cells, also improving the ex vivo purging of malignant progenitors from patient autografts.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1748-6963
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
419-31
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pubmed:meshHeading |
pubmed-meshheading:20394535-Antineoplastic Agents,
pubmed-meshheading:20394535-Apoptosis,
pubmed-meshheading:20394535-Bone Marrow Cells,
pubmed-meshheading:20394535-Capsules,
pubmed-meshheading:20394535-Cell Line, Tumor,
pubmed-meshheading:20394535-Cell Proliferation,
pubmed-meshheading:20394535-Delayed-Action Preparations,
pubmed-meshheading:20394535-Fusion Proteins, bcr-abl,
pubmed-meshheading:20394535-Humans,
pubmed-meshheading:20394535-Leukemia, Myelogenous, Chronic, BCR-ABL Positive,
pubmed-meshheading:20394535-Piperazines,
pubmed-meshheading:20394535-Pyrimidines
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pubmed:year |
2010
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pubmed:articleTitle |
Imatinib-loaded polyelectrolyte microcapsules for sustained targeting of BCR-ABL+ leukemia stem cells.
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pubmed:affiliation |
National Nanotechnology Laboratory of CNR-INFM, IIT Research Unit, Scuola Superiore ISUFI, University of Salento, Via Arnesano 73100 Lecce, Italy.
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pubmed:publicationType |
Journal Article
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