|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
9
|
|
pubmed:dateCreated |
2010-4-30
|
|
pubmed:abstractText |
A series of isoflavone fatty acid esters were designed on the basis of endogenous oleoyl-estrone using estrogen moiety modification strategy. Ten new compounds were synthesized, and their body weight loss and hypolipidemic bioactivities were assayed. Some of these novel compounds could effectively inhibit the differentiation of 3T3-L1 preadipocytes in vitro. The most potent compound 1a significantly decreased the body weight and white adipose tissue weight in a high-fat diet-induced rat model. Also, compound 1a showed good hypolipidemic activity and low toxicity.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
May
|
|
pubmed:issn |
1464-3391
|
|
pubmed:author |
|
|
pubmed:copyrightInfo |
(c) 2010 Elsevier Ltd. All rights reserved.
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
1
|
|
pubmed:volume |
18
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
3036-42
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:20392645-3T3-L1 Cells,
pubmed-meshheading:20392645-Adipocytes,
pubmed-meshheading:20392645-Animals,
pubmed-meshheading:20392645-Anti-Obesity Agents,
pubmed-meshheading:20392645-Cell Differentiation,
pubmed-meshheading:20392645-Cell Line,
pubmed-meshheading:20392645-Esters,
pubmed-meshheading:20392645-Fatty Acids,
pubmed-meshheading:20392645-Flavones,
pubmed-meshheading:20392645-Hypolipidemic Agents,
pubmed-meshheading:20392645-Male,
pubmed-meshheading:20392645-Mice,
pubmed-meshheading:20392645-Mice, Inbred C57BL,
pubmed-meshheading:20392645-Molecular Structure,
pubmed-meshheading:20392645-Rats,
pubmed-meshheading:20392645-Weight Loss
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Synthesis and biological evaluation of isoflavone fatty acid esters with potential weight loss and hypolipidemic activities.
|
|
pubmed:affiliation |
Department of Medicinal Chemistry, School of Pharmacy, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, PR China. cpuxianghua@sina.com
|
|
pubmed:publicationType |
Journal Article
|
