Linked Life Data

20385238

Source:http://linkedlifedata.com/resource/pubmed/id/20385238

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2010-8-4
pubmed:abstractText
Defective mitochondrial DNA (mtDNA) replication is a common cause of human disease in children and adults. mtDNA replication relies on a large set of nuclear-encoded proteins that either belong to the replication machinery itself, or participate in the nucleotide pool regulation. Identification of patient mutations in the corresponding genes has revealed that dysfunctional mtDNA replication can cause highly variable disease phenotypes. We describe here the strategies that have been undertaken to generate mouse models for mtDNA replication diseases. Such models are essential tools for understanding the consequences of mtDNA replication defects on different tissues and on the metabolism of the whole organism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1095-9130
pubmed:author
pubmed:copyrightInfo
Copyright (c) 2010 Elsevier Inc. All rights reserved.
pubmed:issnType
Electronic
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
405-10
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Mouse models of mtDNA replication diseases.
pubmed:affiliation
Biomedicum Helsinki, Research Programme of Molecular Neurology, University of Helsinki, Finland.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't