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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2011-1-19
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pubmed:abstractText |
The cell adhesion molecule integrin ?(v)?(3) is an important player in the process of tumor angiogenesis and metastasis. Abegrin™, a fully humanized anti-integrin ?(v)?(3) monoclonal antibody, was currently in clinical trials for cancer therapy. Herein, we labeled Abegrin™ with (111)In, evaluated the in vitro and in vivo characteristics, and investigated whether the expression of integrin ?(v)?(3) in tumors could be imaged with (111)In-labeled Abegrin™.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1860-2002
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
112-20
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:20383594-Animals,
pubmed-meshheading:20383594-Antibodies, Monoclonal,
pubmed-meshheading:20383594-Antibodies, Monoclonal, Humanized,
pubmed-meshheading:20383594-Cell Line, Tumor,
pubmed-meshheading:20383594-Female,
pubmed-meshheading:20383594-Fluorescent Antibody Technique,
pubmed-meshheading:20383594-Humans,
pubmed-meshheading:20383594-Indium Radioisotopes,
pubmed-meshheading:20383594-Integrin alphaVbeta3,
pubmed-meshheading:20383594-Mice,
pubmed-meshheading:20383594-Mice, Nude,
pubmed-meshheading:20383594-Models, Animal,
pubmed-meshheading:20383594-Tissue Distribution
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pubmed:year |
2011
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pubmed:articleTitle |
Specific targeting of human integrin ?(v)? (3) with (111)In-labeled Abegrin™ in nude mouse models.
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pubmed:affiliation |
Medical Isotopes Research Center and Department of Radiation Medicine, School of Basic Medical Sciences, Peking University, 38 Xueyuan Road, Beijing 100191, China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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