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pubmed-article:20380702pubmed:abstractTextThe past two decades have witnessed an increasing appreciation of the role of the tumor microenvironment, of genetic and epigenetic alterations in normal cells adjacent to tumors and of the migration of normal cells with aberrant intrinsic properties in cancer pathophysiology. Aside from these insights, a novel concept termed "oncoprotein metastasis" (OPM) has recently been advanced and proposed to reflect protein-based neoplastic phenomena that might occur even before any modifications relating to the morphology, location or (epi)genetic outfit of cells during the malignant process. Here, evidence is presented that supports the OPM perception and thus should contribute not only to further rethink the definition of a normal cell, but also the treatment of cancer disease in the years to come.lld:pubmed
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pubmed-article:20380702pubmed:authorpubmed-author:RadulescuRazv...lld:pubmed
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pubmed-article:20380702pubmed:year2010lld:pubmed
pubmed-article:20380702pubmed:articleTitleOncoprotein metastasis and its suppression revisited.lld:pubmed
pubmed-article:20380702pubmed:affiliationMolecular Concepts Research, Muenster, Germany. ratura@gmx.netlld:pubmed
pubmed-article:20380702pubmed:publicationTypeJournal Articlelld:pubmed
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