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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
2010-8-24
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pubmed:abstractText |
Sepsis with subsequent multiorgan dysfunction remains the leading cause of mortality in trauma patients. A gender dimorphism in the host response after trauma and sepsis has been revealed. Dehydroepiandrosterone (DHEA), one of the most abundant adrenal sexual steroid hormones, seems to have a protective immunological effect in sepsis. Knowledge of the pathway is sparse; however, a cellular modulation mediated by interleukin-6 (IL-6) has been proposed.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1662-8128
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pubmed:author |
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pubmed:copyrightInfo |
2010 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
2
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
469-77
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pubmed:meshHeading |
pubmed-meshheading:20375552-Adjuvants, Immunologic,
pubmed-meshheading:20375552-Animals,
pubmed-meshheading:20375552-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20375552-Dehydroepiandrosterone,
pubmed-meshheading:20375552-Disease Models, Animal,
pubmed-meshheading:20375552-Humans,
pubmed-meshheading:20375552-Interleukin-6,
pubmed-meshheading:20375552-Killer Cells, Natural,
pubmed-meshheading:20375552-Lymphocyte Subsets,
pubmed-meshheading:20375552-Male,
pubmed-meshheading:20375552-Mice,
pubmed-meshheading:20375552-Mice, Inbred C57BL,
pubmed-meshheading:20375552-Mice, Knockout,
pubmed-meshheading:20375552-Sepsis,
pubmed-meshheading:20375552-T-Lymphocytes,
pubmed-meshheading:20375552-Treatment Outcome
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pubmed:year |
2010
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pubmed:articleTitle |
Activity of lymphocyte subpopulations in polymicrobial sepsis and DHEA treatment in IL-6 knockout mice.
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pubmed:affiliation |
Trauma Department, Hannover Medical School, Hannover, Germany.
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pubmed:publicationType |
Journal Article
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