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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-4-7
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pubmed:abstractText |
Atypical antipsychotic drugs, in particular clozapine and olanzapine, influence cellular lipogenesis and are associated with metabolic side effects including weight gain. Insulin induced gene 2 (INSIG2) mediates feedback control of lipid synthesis and polymorphisms in the gene (rs17587100, rs10490624 and rs17047764) have been associated with antipsychotic induced weight gain. In this study we intended to replicate these findings in an independent patient population.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1099-1077
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2010 John Wiley & Sons, Ltd.
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pubmed:issnType |
Electronic
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
253-9
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pubmed:meshHeading |
pubmed-meshheading:20373477-Adult,
pubmed-meshheading:20373477-African Americans,
pubmed-meshheading:20373477-Antipsychotic Agents,
pubmed-meshheading:20373477-Double-Blind Method,
pubmed-meshheading:20373477-European Continental Ancestry Group,
pubmed-meshheading:20373477-Female,
pubmed-meshheading:20373477-Genetic Association Studies,
pubmed-meshheading:20373477-Humans,
pubmed-meshheading:20373477-Intracellular Signaling Peptides and Proteins,
pubmed-meshheading:20373477-Longitudinal Studies,
pubmed-meshheading:20373477-Male,
pubmed-meshheading:20373477-Membrane Proteins,
pubmed-meshheading:20373477-Middle Aged,
pubmed-meshheading:20373477-Polymorphism, Single Nucleotide,
pubmed-meshheading:20373477-Schizophrenia,
pubmed-meshheading:20373477-Weight Gain,
pubmed-meshheading:20373477-Young Adult
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pubmed:year |
2010
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pubmed:articleTitle |
Association study of polymorphisms in insulin induced gene 2 (INSIG2) with antipsychotic-induced weight gain in European and African-American schizophrenia patients.
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pubmed:affiliation |
Neuroscience Department, Centre for Addiction and Mental Health, Toronto, Ontario, Canada.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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