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pubmed-article:20368814pubmed:abstractTextCardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regulated kinases 1/2 (ERK1/2) and RhoA [activated by hypertrophic agonists (e.g. endothelin-1)] regulate gene expression and are implicated in the response, but their relative significance in regulating the cardiomyocyte transcriptome is unknown. Our aim was to establish the significance of ERK1/2 and/or RhoA in the early cardiomyocyte transcriptomic response to endothelin-1.lld:pubmed
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pubmed-article:20368814pubmed:articleTitleERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes.lld:pubmed
pubmed-article:20368814pubmed:affiliationNational Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom.lld:pubmed
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