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rdf:type |
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lifeskim:mentions |
umls-concept:C0021289,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0037083,
umls-concept:C0040649,
umls-concept:C0079281,
umls-concept:C0205263,
umls-concept:C0225828,
umls-concept:C0392747,
umls-concept:C0443172,
umls-concept:C1366765,
umls-concept:C1710082,
umls-concept:C1998811
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pubmed:issue |
4
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pubmed:dateCreated |
2010-4-6
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pubmed:abstractText |
Cardiomyocyte hypertrophy is associated with changes in gene expression. Extracellular signal-regulated kinases 1/2 (ERK1/2) and RhoA [activated by hypertrophic agonists (e.g. endothelin-1)] regulate gene expression and are implicated in the response, but their relative significance in regulating the cardiomyocyte transcriptome is unknown. Our aim was to establish the significance of ERK1/2 and/or RhoA in the early cardiomyocyte transcriptomic response to endothelin-1.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-10998351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-11158304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-11299284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-12805233,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-12878473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-15240006,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-15637050,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-15822172,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-15905459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-16043642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-16443044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-16574914,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-16756989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-16778073,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-17146673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-17234627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-17322878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-17389260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-17450511,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-17452038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-18246092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-18275597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-18430438,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-18687805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-19855013,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-8530360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-8694751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20368814-9679149
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
5
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e10027
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pubmed:meshHeading |
pubmed-meshheading:20368814-Animals,
pubmed-meshheading:20368814-Animals, Newborn,
pubmed-meshheading:20368814-Cells, Cultured,
pubmed-meshheading:20368814-Endothelin-1,
pubmed-meshheading:20368814-Enzyme Inhibitors,
pubmed-meshheading:20368814-Gene Expression Profiling,
pubmed-meshheading:20368814-Gene Expression Regulation,
pubmed-meshheading:20368814-Hypertrophy,
pubmed-meshheading:20368814-Mitogen-Activated Protein Kinase 1,
pubmed-meshheading:20368814-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:20368814-Myocytes, Cardiac,
pubmed-meshheading:20368814-RNA, Messenger,
pubmed-meshheading:20368814-Rats,
pubmed-meshheading:20368814-Signal Transduction,
pubmed-meshheading:20368814-Time Factors,
pubmed-meshheading:20368814-rhoA GTP-Binding Protein
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pubmed:year |
2010
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pubmed:articleTitle |
ERK1/2 signaling dominates over RhoA signaling in regulating early changes in RNA expression induced by endothelin-1 in neonatal rat cardiomyocytes.
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pubmed:affiliation |
National Heart and Lung Institute, Faculty of Medicine, Imperial College London, London, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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