| pubmed-article:20363288 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20363288 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:20363288 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:20363288 | lifeskim:mentions | umls-concept:C1257975 | lld:lifeskim |
| pubmed-article:20363288 | lifeskim:mentions | umls-concept:C0596843 | lld:lifeskim |
| pubmed-article:20363288 | lifeskim:mentions | umls-concept:C0010531 | lld:lifeskim |
| pubmed-article:20363288 | lifeskim:mentions | umls-concept:C0001455 | lld:lifeskim |
| pubmed-article:20363288 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:20363288 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:20363288 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:20363288 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:20363288 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:20363288 | pubmed:dateCreated | 2010-5-24 | lld:pubmed |
| pubmed-article:20363288 | pubmed:abstractText | The adipogenic capacity of mesenchymal stem cells (MSCs) and the involvement of beta-adrenergic signals in lipolysis and thermogenesis have been well established. However, little is known about the development of beta-adrenergic receptor (beta-AR) systems and the role of beta-adrenergic signals in adipogenic differentiation of MSCs. In this study, we demonstrated that both the mRNA and protein levels of beta2- and beta3-AR were up-regulated following adipogenesis of mouse bone marrow derived MSCs. We also established that beta-AR agonists negatively while antagonists positively affected MSC adipogenesis. Both the beta2- and beta3-AR were involved in MSC adipogenesis, with beta3-AR being the predominant subtype. The effect of beta-ARs on MSC adipogenesis was at least partly mediated via the cAMP/PKA signaling pathway. These findings suggested that MSC is also a target for beta-adrenergic regulation, and beta-adrenergic signaling (major beta3-signaling) plays a role in MSC adipogenesis. | lld:pubmed |
| pubmed-article:20363288 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20363288 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20363288 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:20363288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20363288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20363288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20363288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20363288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20363288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20363288 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20363288 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20363288 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:20363288 | pubmed:issn | 1872-8057 | lld:pubmed |
| pubmed-article:20363288 | pubmed:author | pubmed-author:YangMengsuM | lld:pubmed |
| pubmed-article:20363288 | pubmed:author | pubmed-author:CaiGuopingG | lld:pubmed |
| pubmed-article:20363288 | pubmed:author | pubmed-author:LiHaifangH | lld:pubmed |
| pubmed-article:20363288 | pubmed:author | pubmed-author:ChenYaoY | lld:pubmed |
| pubmed-article:20363288 | pubmed:author | pubmed-author:FongChichunC | lld:pubmed |
| pubmed-article:20363288 | pubmed:copyrightInfo | 2010 Elsevier Ireland Ltd. All rights reserved. | lld:pubmed |
| pubmed-article:20363288 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20363288 | pubmed:day | 29 | lld:pubmed |
| pubmed-article:20363288 | pubmed:volume | 323 | lld:pubmed |
| pubmed-article:20363288 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20363288 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20363288 | pubmed:pagination | 201-7 | lld:pubmed |
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| pubmed-article:20363288 | pubmed:meshHeading | pubmed-meshheading:20363288... | lld:pubmed |
| pubmed-article:20363288 | pubmed:meshHeading | pubmed-meshheading:20363288... | lld:pubmed |
| pubmed-article:20363288 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20363288 | pubmed:articleTitle | Beta-adrenergic signals regulate adipogenesis of mouse mesenchymal stem cells via cAMP/PKA pathway. | lld:pubmed |
| pubmed-article:20363288 | pubmed:affiliation | Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, PR China. | lld:pubmed |
| pubmed-article:20363288 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:20363288 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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