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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-5-24
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pubmed:abstractText |
The adipogenic capacity of mesenchymal stem cells (MSCs) and the involvement of beta-adrenergic signals in lipolysis and thermogenesis have been well established. However, little is known about the development of beta-adrenergic receptor (beta-AR) systems and the role of beta-adrenergic signals in adipogenic differentiation of MSCs. In this study, we demonstrated that both the mRNA and protein levels of beta2- and beta3-AR were up-regulated following adipogenesis of mouse bone marrow derived MSCs. We also established that beta-AR agonists negatively while antagonists positively affected MSC adipogenesis. Both the beta2- and beta3-AR were involved in MSC adipogenesis, with beta3-AR being the predominant subtype. The effect of beta-ARs on MSC adipogenesis was at least partly mediated via the cAMP/PKA signaling pathway. These findings suggested that MSC is also a target for beta-adrenergic regulation, and beta-adrenergic signaling (major beta3-signaling) plays a role in MSC adipogenesis.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Agonists,
http://linkedlifedata.com/resource/pubmed/chemical/Adrenergic beta-Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclic AMP-Dependent Protein Kinases,
http://linkedlifedata.com/resource/pubmed/chemical/Isoproterenol,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-2,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Adrenergic, beta-3
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1872-8057
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pubmed:author |
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pubmed:copyrightInfo |
2010 Elsevier Ireland Ltd. All rights reserved.
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pubmed:issnType |
Electronic
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pubmed:day |
29
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pubmed:volume |
323
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-7
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pubmed:meshHeading |
pubmed-meshheading:20363288-Adipocytes,
pubmed-meshheading:20363288-Adipogenesis,
pubmed-meshheading:20363288-Adrenergic beta-Agonists,
pubmed-meshheading:20363288-Adrenergic beta-Antagonists,
pubmed-meshheading:20363288-Animals,
pubmed-meshheading:20363288-Cell Differentiation,
pubmed-meshheading:20363288-Cells, Cultured,
pubmed-meshheading:20363288-Cyclic AMP,
pubmed-meshheading:20363288-Cyclic AMP-Dependent Protein Kinases,
pubmed-meshheading:20363288-Dose-Response Relationship, Drug,
pubmed-meshheading:20363288-Female,
pubmed-meshheading:20363288-Isoproterenol,
pubmed-meshheading:20363288-Mesenchymal Stem Cells,
pubmed-meshheading:20363288-Mice,
pubmed-meshheading:20363288-Receptors, Adrenergic, beta-2,
pubmed-meshheading:20363288-Receptors, Adrenergic, beta-3,
pubmed-meshheading:20363288-Signal Transduction
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pubmed:year |
2010
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pubmed:articleTitle |
Beta-adrenergic signals regulate adipogenesis of mouse mesenchymal stem cells via cAMP/PKA pathway.
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pubmed:affiliation |
Department of Biological Sciences and Biotechnology, Tsinghua University, Beijing 100084, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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