Linked Life Data

20362647

Source:http://linkedlifedata.com/resource/pubmed/id/20362647

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2010-5-14
pubmed:abstractText
There is increasing evidence that exposure to air pollutants during pregnancy can result in a number of deleterious effects including low birth weight and the incidence of allergic asthma. To investigate the in utero effects of DE exposure, timed pregnant BALB/c mice were exposed to 0, 0.8 or 3.1 mg/m(3) of DE during gestation days (GD) 9 to GD 18. The number of successful pregnancies was 15/20 in the air controls and 10/20 in each of the diesel exposures. Immune function in the 6-week-old offspring as determined by development of delayed type hypersensitivity (DTH) reactions to bovine serum albumin (BSA), antibody titers to injected sheep red blood cells (SRBC), splenic T cells expressing CD45(+)CD3(+)CD8(+) and CD3(+)CD25(+), and mRNA expression of TNF-alpha, TLR2, SP-A, TGF-beta and Foxp3 in the lung were not affected by prenatal DE exposure. On the other hand, lung TLR4 mRNA expression, the number of neutrophils in the bronchoalveolar lavage fluid (BALF) and splenic T cells expressing CD45(+)CD3(+)CD4(+) and CD4(+)CD25(+) were differentially affected depending on the DE concentration and gender. When additional groups of mice were sensitized and challenged via the respiratory tract with ovalbumin to induce allergic airway inflammation, female mice had higher protein levels in the BALF compared to males and this was reduced by prenatal exposure to either concentration of DE. No other changes in allergen-induced immunity, lung function or severity of inflammation were noted. Collectively, the results show that in utero exposure to DE altered some baseline inflammatory indices in the lung in a gender-specific manner, but had no effect on development of specific immune responses to experimental antigens, or the severity of allergic lung inflammation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1879-3169
pubmed:author
pubmed:copyrightInfo
Published by Elsevier Ireland Ltd.
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
196
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
12-20
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Effects of prenatal diesel exhaust inhalation on pulmonary inflammation and development of specific immune responses.
pubmed:affiliation
Cardiopulmonary and Immunotoxicology Branch, Environmental Public Health Division, NHEERL, US Environmental Protection Agency (EPA), Research Triangle Park, North Carolina 27711, United States.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.