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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2010-6-18
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pubmed:abstractText |
Matrix metalloproteinases (MMPs) have various roles in inflammatory states. They seem to be able to modulate endothelial barriers and regulate the activity of chemokines and cytokines. The timely development of the levels during severe sepsis and thereafter have not been investigated. In addition it was of interest to study alterations of MMP-levels in intact skin, as the skin is the largest barrier against external pathogens and MMPs have not been studied at organ level in human sepsis. The aim of this study was to investigate the timely development of serum and skin MMP-2, -8 and -9 levels in human severe sepsis and their association with disease severity and mortality.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20356362-10030844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20356362-10652271,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20356362-10786961,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20356362-11023497,
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1466-609X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
R49
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pubmed:meshHeading |
pubmed-meshheading:20356362-Aged,
pubmed-meshheading:20356362-Blister,
pubmed-meshheading:20356362-Disease Progression,
pubmed-meshheading:20356362-Female,
pubmed-meshheading:20356362-Humans,
pubmed-meshheading:20356362-Longitudinal Studies,
pubmed-meshheading:20356362-Male,
pubmed-meshheading:20356362-Matrix Metalloproteinases, Secreted,
pubmed-meshheading:20356362-Middle Aged,
pubmed-meshheading:20356362-Prospective Studies,
pubmed-meshheading:20356362-Sepsis,
pubmed-meshheading:20356362-Severity of Illness Index,
pubmed-meshheading:20356362-Skin,
pubmed-meshheading:20356362-Up-Regulation
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pubmed:year |
2010
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pubmed:articleTitle |
Matrix-metalloproteinase-2, -8 and -9 in serum and skin blister fluid in patients with severe sepsis.
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pubmed:affiliation |
Department of Anesthesiology, Division of Intensive Care, Oulu University Hospital, Kajaanintie 50, Oulu, Finland. fpeltola@mail.student.oulu.fi
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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