|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0011306,
umls-concept:C0205100,
umls-concept:C0376315,
umls-concept:C0439849,
umls-concept:C0439858,
umls-concept:C0445223,
umls-concept:C1141628,
umls-concept:C1515021,
umls-concept:C1548174,
umls-concept:C1552599,
umls-concept:C1704787,
umls-concept:C1706076
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2010-4-13
|
|
pubmed:abstractText |
Although CD103-expressing dendritic cells (DCs) are widely present in nonlymphoid tissues, the transcription factors controlling their development and their relationship to other DC subsets remain unclear. Mice lacking the transcription factor Batf3 have a defect in the development of CD8alpha+ conventional DCs (cDCs) within lymphoid tissues. We demonstrate that Batf3(-/-) mice also lack CD103+CD11b- DCs in the lung, intestine, mesenteric lymph nodes (MLNs), dermis, and skin-draining lymph nodes. Notably, Batf3(-/-) mice displayed reduced priming of CD8 T cells after pulmonary Sendai virus infection, with increased pulmonary inflammation. In the MLNs and intestine, Batf3 deficiency resulted in the specific lack of CD103+CD11b- DCs, with the population of CD103+CD11b+ DCs remaining intact. Batf3(-/-) mice showed no evidence of spontaneous gastrointestinal inflammation and had a normal contact hypersensitivity (CHS) response, despite previous suggestions that CD103+ DCs were required for immune homeostasis in the gut and CHS. The relationship between CD8alpha+ cDCs and nonlymphoid CD103+ DCs implied by their shared dependence on Batf3 was further supported by similar patterns of gene expression and their shared developmental dependence on the transcription factor Irf8. These data provide evidence for a developmental relationship between lymphoid organ-resident CD8alpha+ cDCs and nonlymphoid CD103+ DCs.
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD8,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Surface,
http://linkedlifedata.com/resource/pubmed/chemical/Basic-Leucine Zipper Transcription...,
http://linkedlifedata.com/resource/pubmed/chemical/CD8 antigen, alpha chain,
http://linkedlifedata.com/resource/pubmed/chemical/Dinitrofluorobenzene,
http://linkedlifedata.com/resource/pubmed/chemical/Flt3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin alpha Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Macrophage...,
http://linkedlifedata.com/resource/pubmed/chemical/Repressor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/SNFT protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/alpha E integrins,
http://linkedlifedata.com/resource/pubmed/chemical/fms-Like Tyrosine Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/interferon regulatory factor-8
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1540-9538
|
|
pubmed:author |
pubmed-author:AlbringJörn CJC,
pubmed-author:BenoitLoralyn ALA,
pubmed-author:BhattacharyaDeeptaD,
pubmed-author:EdelsonBrian TBT,
pubmed-author:HildnerKaiK,
pubmed-author:HoltzmanMichael JMJ,
pubmed-author:IseWataruW,
pubmed-author:JuangRichardR,
pubmed-author:KCWumeshW,
pubmed-author:KlekotkaPaul APA,
pubmed-author:KohyamaMasakoM,
pubmed-author:MichaelDrew GDG,
pubmed-author:MoonClaraC,
pubmed-author:MurphyKenneth MKM,
pubmed-author:MurphyTheresa LTL,
pubmed-author:StappenbeckThaddeus STS,
pubmed-author:SungSun-Sang JSS
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
12
|
|
pubmed:volume |
207
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
823-36
|
|
pubmed:dateRevised |
2010-10-13
|
|
pubmed:meshHeading |
pubmed-meshheading:20351058-Animals,
pubmed-meshheading:20351058-Antigens, CD,
pubmed-meshheading:20351058-Antigens, CD8,
pubmed-meshheading:20351058-Antigens, Surface,
pubmed-meshheading:20351058-Basic-Leucine Zipper Transcription Factors,
pubmed-meshheading:20351058-Dendritic Cells,
pubmed-meshheading:20351058-Dermatitis, Contact,
pubmed-meshheading:20351058-Dinitrofluorobenzene,
pubmed-meshheading:20351058-Female,
pubmed-meshheading:20351058-Gene Expression,
pubmed-meshheading:20351058-Integrin alpha Chains,
pubmed-meshheading:20351058-Interferon Regulatory Factors,
pubmed-meshheading:20351058-Intestinal Mucosa,
pubmed-meshheading:20351058-Lung,
pubmed-meshheading:20351058-Lymph Nodes,
pubmed-meshheading:20351058-Male,
pubmed-meshheading:20351058-Mesentery,
pubmed-meshheading:20351058-Mice,
pubmed-meshheading:20351058-Mice, Inbred C3H,
pubmed-meshheading:20351058-Mice, Inbred C57BL,
pubmed-meshheading:20351058-Mice, Knockout,
pubmed-meshheading:20351058-Mice, Mutant Strains,
pubmed-meshheading:20351058-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:20351058-Receptor, Macrophage Colony-Stimulating Factor,
pubmed-meshheading:20351058-Repressor Proteins,
pubmed-meshheading:20351058-Respirovirus Infections,
pubmed-meshheading:20351058-Sendai virus,
pubmed-meshheading:20351058-Skin,
pubmed-meshheading:20351058-T-Lymphocytes,
pubmed-meshheading:20351058-Transcription Factors,
pubmed-meshheading:20351058-fms-Like Tyrosine Kinase 3
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Peripheral CD103+ dendritic cells form a unified subset developmentally related to CD8alpha+ conventional dendritic cells.
|
|
pubmed:affiliation |
Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
