Linked Life Data

20350950

Source:http://linkedlifedata.com/resource/pubmed/id/20350950

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
2010-6-17
pubmed:abstractText
Sporadic isolates of carbapenem-resistant KPC-2-producing Klebsiella pneumoniae were isolated in Tel Aviv Medical Center during 2005 and 2006, parallel to the emergence of the KPC-3-producing K. pneumoniae sequence type 258 (ST 258). We aimed to study the molecular epidemiology of these isolates and to characterize their bla(KPC)-carrying plasmids and their origin. Ten isolates (8 KPC-2 and 2 KPC-3 producing) were studied. All isolates were extremely drug resistant. They possessed the bla(KPC) gene and varied in their additional beta-lactamase contents. The KPC-2-producing strains belonged to three different sequence types: ST 340 (n = 2), ST 277 (n = 2), and a novel sequence type, ST 376 (n = 4). Among KPC-3-producing strains, a single isolate (ST 327) different from ST 258 was identified, but both strains carried the same plasmid (pKpQIL). The KPC-2-encoding plasmids varied in size (45 to 95 kb) and differed among each of the STs. Two of the Klebsiella bla(KPC-2)-carrying plasmids were identical to plasmids from Escherichia coli, suggesting a common origin of these plasmids. These data indicate that KPC evolution in K. pneumoniae is related to rare events of interspecies spread of bla(KPC-2)-carrying plasmids from E. coli followed by limited clonal spread, whereas KPC-3 carriage in this species is related almost strictly to clonal expansion of ST 258 carrying pKpQIL.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-16940107, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-17562800, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-18086836, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-18519713, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-18812425, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-19029323, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-19109119, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-19218573, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-19324295, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-19496647, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-19506063, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-19620323, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-19656782, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-19759220, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-19939824, http://linkedlifedata.com/resource/pubmed/commentcorrection/20350950-20231393
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1098-6596
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
3002-6
pubmed:dateRevised
2011-7-19
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Molecular epidemiology, sequence types, and plasmid analyses of KPC-producing Klebsiella pneumoniae strains in Israel.
pubmed:affiliation
Molecular Epidemiology and Antimicrobial Resistance Laboratory, Division of Epidemiology, Tel Aviv Medical Center, Tel Aviv, Israel.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't