Linked Life Data

2034036

Source:http://linkedlifedata.com/resource/pubmed/id/2034036

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pubmed-article:2034036pubmed:abstractTextThe effect of the antiestrogen 4-hydroxytamoxifen on the estradiol-stimulated acetylation of nuclear high mobility group (HMG) proteins was studied in the uterus of newborn (3-day-old) guinea-pig. 4-Hydroxytamoxifen (10(-6) M) selectively inhibits the stimulatory effect of estradiol (5 x 10(-8) M) on the acetylation of HMG-14 proteins 30 min after incubation with uterine tissue slices. No effect of 4-hydroxytamoxifen was observed on HMG-1 + HMG-2 or HMG-17 proteins. The data suggest that the blockage of HMG-14 acetylation is an early event in gene expression which is in relation to the antagonistic effect of the antiestrogen.lld:pubmed
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pubmed-article:2034036pubmed:articleTitleAntagonistic effect of the antiestrogen 4-hydroxytamoxifen on estradiol-stimulated acetylation of nuclear high mobility group (HMG) proteins in the uterus of newborn guinea-pigs.lld:pubmed
pubmed-article:2034036pubmed:affiliationC.N.R.S. Steroid Hormone Research Unit, Foundation for Hormone Research, Paris, France.lld:pubmed
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pubmed-article:2034036pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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