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rdf:type |
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lifeskim:mentions |
umls-concept:C0001038,
umls-concept:C0014930,
umls-concept:C0021289,
umls-concept:C0033684,
umls-concept:C0042149,
umls-concept:C0048403,
umls-concept:C0085979,
umls-concept:C0425245,
umls-concept:C0521447,
umls-concept:C1257890,
umls-concept:C1280500
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pubmed:issue |
21
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pubmed:dateCreated |
1991-6-21
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pubmed:abstractText |
The effect of the antiestrogen 4-hydroxytamoxifen on the estradiol-stimulated acetylation of nuclear high mobility group (HMG) proteins was studied in the uterus of newborn (3-day-old) guinea-pig. 4-Hydroxytamoxifen (10(-6) M) selectively inhibits the stimulatory effect of estradiol (5 x 10(-8) M) on the acetylation of HMG-14 proteins 30 min after incubation with uterine tissue slices. No effect of 4-hydroxytamoxifen was observed on HMG-1 + HMG-2 or HMG-17 proteins. The data suggest that the blockage of HMG-14 acetylation is an early event in gene expression which is in relation to the antagonistic effect of the antiestrogen.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,2-epoxy-1-(4-nitrophenyl)pentane,
http://linkedlifedata.com/resource/pubmed/chemical/4-hydroxytamoxifen,
http://linkedlifedata.com/resource/pubmed/chemical/Butyric Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Butyric Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Epoxy Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Estradiol,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/High Mobility Group Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrobenzenes,
http://linkedlifedata.com/resource/pubmed/chemical/Phenylmethylsulfonyl Fluoride,
http://linkedlifedata.com/resource/pubmed/chemical/Protease Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Tamoxifen,
http://linkedlifedata.com/resource/pubmed/chemical/Trypsin Inhibitors
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pubmed:status |
MEDLINE
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pubmed:issn |
0024-3205
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
48
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2081-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:2034036-Acetylation,
pubmed-meshheading:2034036-Animals,
pubmed-meshheading:2034036-Animals, Newborn,
pubmed-meshheading:2034036-Butyric Acid,
pubmed-meshheading:2034036-Butyric Acids,
pubmed-meshheading:2034036-Cell Nucleus,
pubmed-meshheading:2034036-Epoxy Compounds,
pubmed-meshheading:2034036-Estradiol,
pubmed-meshheading:2034036-Estrogen Antagonists,
pubmed-meshheading:2034036-Female,
pubmed-meshheading:2034036-Guinea Pigs,
pubmed-meshheading:2034036-High Mobility Group Proteins,
pubmed-meshheading:2034036-Nitrobenzenes,
pubmed-meshheading:2034036-Phenylmethylsulfonyl Fluoride,
pubmed-meshheading:2034036-Protease Inhibitors,
pubmed-meshheading:2034036-Tamoxifen,
pubmed-meshheading:2034036-Trypsin Inhibitors,
pubmed-meshheading:2034036-Uterus
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pubmed:year |
1991
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pubmed:articleTitle |
Antagonistic effect of the antiestrogen 4-hydroxytamoxifen on estradiol-stimulated acetylation of nuclear high mobility group (HMG) proteins in the uterus of newborn guinea-pigs.
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pubmed:affiliation |
C.N.R.S. Steroid Hormone Research Unit, Foundation for Hormone Research, Paris, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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