Linked Life Data

20333693

Source:http://linkedlifedata.com/resource/pubmed/id/20333693

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-4-21
pubmed:abstractText
The effect of the luminescent heteroaromatic electron acceptor N,N'-dimethyl-2,7-diazapyrenium dichloride (DM-DAP(2+)) on the stability of 1-palmitoyl-2-oleoylphosphatydilcholine (POPC) liposomes is determined on the basis of the rate of release of different fluorescent probes entrapped within the liposome. The experiments show that DM-DAP(2+) exerts a substantial destabilizing action on the liposomal bilayer, particularly at low concentrations. Molecular dynamics simulations suggest that the activity of DM-DAP(2+) is related to its tendency to surround itself with water molecules, conceivably favoring the formation of transient pores across the bilayer.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1613-6829
pubmed:author
pubmed:issnType
Electronic
pubmed:day
23
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
952-9
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Liposome destabilization by a 2,7-diazapyrenium derivative through formation of transient pores in the lipid bilayer.
pubmed:affiliation
Dipartimento di Scienze del Farmaco Università G. d'Annunzio Via dei Vestini, 66013 Chieti, Italy.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't