|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
10
|
|
pubmed:dateCreated |
2010-10-18
|
|
pubmed:abstractText |
Myelotoxicity has been shown to be very common in Korean patients with inflammatory bowel disease (IBD) during azathioprine (AZA) or 6-mercaptopurine (6-MP) treatment. The purpose of this study was to investigate the relative risk of the thiopurine methyltransferase (TPMT) and inosine triphosphate pyrophosphatase (ITPA) genotypes and TPMT activity for the development of leukopenia in Korean IBD patients during AZA/6-MP treatment.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1539-2031
|
|
pubmed:author |
pubmed-author:ByeonJeong-SikJS,
pubmed-author:CheonJae HeeJH,
pubmed-author:EunChang SooCS,
pubmed-author:HanDong SooDS,
pubmed-author:HongSeong SooSS,
pubmed-author:HongSung YiSY,
pubmed-author:KimBo-YoungBY,
pubmed-author:KimJae HakJH,
pubmed-author:KimSeung WonSW,
pubmed-author:KimWon HoWH,
pubmed-author:KwonSoon-HoSH,
pubmed-author:YangSuk-KyunSK
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
44
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
e242-8
|
|
pubmed:meshHeading |
pubmed-meshheading:20308917-6-Mercaptopurine,
pubmed-meshheading:20308917-Academic Medical Centers,
pubmed-meshheading:20308917-Adolescent,
pubmed-meshheading:20308917-Adult,
pubmed-meshheading:20308917-Anti-Inflammatory Agents,
pubmed-meshheading:20308917-Asian Continental Ancestry Group,
pubmed-meshheading:20308917-Chi-Square Distribution,
pubmed-meshheading:20308917-Chromatography, High Pressure Liquid,
pubmed-meshheading:20308917-Female,
pubmed-meshheading:20308917-Gastrointestinal Agents,
pubmed-meshheading:20308917-Genetic Predisposition to Disease,
pubmed-meshheading:20308917-Heterozygote,
pubmed-meshheading:20308917-Homozygote,
pubmed-meshheading:20308917-Humans,
pubmed-meshheading:20308917-Inflammatory Bowel Diseases,
pubmed-meshheading:20308917-Kaplan-Meier Estimate,
pubmed-meshheading:20308917-Leukopenia,
pubmed-meshheading:20308917-Male,
pubmed-meshheading:20308917-Methyltransferases,
pubmed-meshheading:20308917-Phenotype,
pubmed-meshheading:20308917-Proportional Hazards Models,
pubmed-meshheading:20308917-Pyrophosphatases,
pubmed-meshheading:20308917-Republic of Korea,
pubmed-meshheading:20308917-Retrospective Studies,
pubmed-meshheading:20308917-Risk Assessment,
pubmed-meshheading:20308917-Risk Factors,
pubmed-meshheading:20308917-Tandem Mass Spectrometry,
pubmed-meshheading:20308917-Treatment Outcome,
pubmed-meshheading:20308917-Young Adult
|
|
pubmed:articleTitle |
Influences of thiopurine methyltransferase genotype and activity on thiopurine-induced leukopenia in Korean patients with inflammatory bowel disease: a retrospective cohort study.
|
|
pubmed:affiliation |
Department of Internal Medicine, Dongguk University College of Medicine, Goyang-si, Korea.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Multicenter Study
|
