pubmed-article:20300982 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:20300982 | lifeskim:mentions | umls-concept:C0007634 | lld:lifeskim |
pubmed-article:20300982 | lifeskim:mentions | umls-concept:C0005961 | lld:lifeskim |
pubmed-article:20300982 | lifeskim:mentions | umls-concept:C0237868 | lld:lifeskim |
pubmed-article:20300982 | lifeskim:mentions | umls-concept:C1167395 | lld:lifeskim |
pubmed-article:20300982 | lifeskim:mentions | umls-concept:C0018133 | lld:lifeskim |
pubmed-article:20300982 | lifeskim:mentions | umls-concept:C0679823 | lld:lifeskim |
pubmed-article:20300982 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
pubmed-article:20300982 | lifeskim:mentions | umls-concept:C0036679 | lld:lifeskim |
pubmed-article:20300982 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
pubmed-article:20300982 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
pubmed-article:20300982 | pubmed:issue | 3 | lld:pubmed |
pubmed-article:20300982 | pubmed:dateCreated | 2010-4-5 | lld:pubmed |
pubmed-article:20300982 | pubmed:abstractText | Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with both graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effects. In clinical studies of HLA-mismatched HSCT, strong GVL effects have been reported. In the present study, we addressed the mechanism of the GVL and GVH response using MHC-haploidentical murine bone marrow transplantation (BMT) models. Recipient BDF1 (H-2(b/d)) mice received T cell-depleted bone marrow and spleen cells from B6C3F1 (H-2(b/k)) or C57BL/6 (H-2(b)) mice with or without P815 mastocytoma cells (H-2(d)) after receiving lethal total body irradiation. B6C3F1 --> BDF1 (hetero-to-hetero type) recipients showed more powerful antileukemic effects with less severe GVHD than C57BL/6 --> BDF1 (parent-to-F1 type) recipients. Compared with C57BL/6 --> BDF1 recipients, significantly higher in vitro cytotoxic activity against P815 cells was observed in B6C3F1 --> BDF1 recipients. Significantly lower CXCR3 expression on donor T cells and higher interferon (IFN)-gamma expression were considered to be associated with strong antileukemic effects with less severe GVHD in B6C3F1 --> BDF1 recipients. Furthermore, host immune cells, especially natural killer cells and CD8(+) T cells, were found to contribute remarkably to high IFN-gamma production in B6C3F1 --> BDF1 recipients. Thus, in MHC-haploidentical HSCT, host immune cells may change the balance between GVH and GVL response through IFN-gamma production. | lld:pubmed |
pubmed-article:20300982 | pubmed:language | eng | lld:pubmed |
pubmed-article:20300982 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20300982 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:20300982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20300982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20300982 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:20300982 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:20300982 | pubmed:month | Apr | lld:pubmed |
pubmed-article:20300982 | pubmed:issn | 1865-3774 | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:TamakiHiroyaH | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:FujiokaTatsuy... | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:OgawaHiroyasu... | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:OkadaMasayaM | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:OkamuraHaruki... | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:IkegameKazuhi... | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:TaniguchiYuki... | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:YoshiharaSato... | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:KuboShujiS | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:SatakeAtsushi... | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:ImadoTakehito... | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:InoueTakayuki... | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:XuYunfengY | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:KaidaKatsujiK | lld:pubmed |
pubmed-article:20300982 | pubmed:author | pubmed-author:HoriuchiMarik... | lld:pubmed |
pubmed-article:20300982 | pubmed:issnType | Electronic | lld:pubmed |
pubmed-article:20300982 | pubmed:volume | 91 | lld:pubmed |
pubmed-article:20300982 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:20300982 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:20300982 | pubmed:pagination | 485-97 | lld:pubmed |
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pubmed-article:20300982 | pubmed:year | 2010 | lld:pubmed |
pubmed-article:20300982 | pubmed:articleTitle | Separation of antileukemic effects from graft-versus-host disease in MHC-haploidentical murine bone marrow transplantation: participation of host immune cells. | lld:pubmed |
pubmed-article:20300982 | pubmed:affiliation | Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan. | lld:pubmed |
pubmed-article:20300982 | pubmed:publicationType | Journal Article | lld:pubmed |