Source:http://linkedlifedata.com/resource/pubmed/id/20300982
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2010-4-5
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| pubmed:abstractText |
Allogeneic hematopoietic stem cell transplantation (HSCT) is associated with both graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) effects. In clinical studies of HLA-mismatched HSCT, strong GVL effects have been reported. In the present study, we addressed the mechanism of the GVL and GVH response using MHC-haploidentical murine bone marrow transplantation (BMT) models. Recipient BDF1 (H-2(b/d)) mice received T cell-depleted bone marrow and spleen cells from B6C3F1 (H-2(b/k)) or C57BL/6 (H-2(b)) mice with or without P815 mastocytoma cells (H-2(d)) after receiving lethal total body irradiation. B6C3F1 --> BDF1 (hetero-to-hetero type) recipients showed more powerful antileukemic effects with less severe GVHD than C57BL/6 --> BDF1 (parent-to-F1 type) recipients. Compared with C57BL/6 --> BDF1 recipients, significantly higher in vitro cytotoxic activity against P815 cells was observed in B6C3F1 --> BDF1 recipients. Significantly lower CXCR3 expression on donor T cells and higher interferon (IFN)-gamma expression were considered to be associated with strong antileukemic effects with less severe GVHD in B6C3F1 --> BDF1 recipients. Furthermore, host immune cells, especially natural killer cells and CD8(+) T cells, were found to contribute remarkably to high IFN-gamma production in B6C3F1 --> BDF1 recipients. Thus, in MHC-haploidentical HSCT, host immune cells may change the balance between GVH and GVL response through IFN-gamma production.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Apr
|
| pubmed:issn |
1865-3774
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| pubmed:author |
pubmed-author:FujiokaTatsuyaT,
pubmed-author:HoriuchiMarikaM,
pubmed-author:IkegameKazuhiroK,
pubmed-author:ImadoTakehitoT,
pubmed-author:InoueTakayukiT,
pubmed-author:KaidaKatsujiK,
pubmed-author:KuboShujiS,
pubmed-author:OgawaHiroyasuH,
pubmed-author:OkadaMasayaM,
pubmed-author:OkamuraHarukiH,
pubmed-author:SatakeAtsushiA,
pubmed-author:TamakiHiroyaH,
pubmed-author:TaniguchiYukiY,
pubmed-author:XuYunfengY,
pubmed-author:YoshiharaSatoshiS
|
| pubmed:issnType |
Electronic
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| pubmed:volume |
91
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
485-97
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| pubmed:meshHeading |
pubmed-meshheading:20300982-Animals,
pubmed-meshheading:20300982-Bone Marrow Transplantation,
pubmed-meshheading:20300982-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20300982-Cells, Cultured,
pubmed-meshheading:20300982-Female,
pubmed-meshheading:20300982-Flow Cytometry,
pubmed-meshheading:20300982-Graft vs Host Disease,
pubmed-meshheading:20300982-Graft vs Leukemia Effect,
pubmed-meshheading:20300982-Haplotypes,
pubmed-meshheading:20300982-Histocompatibility,
pubmed-meshheading:20300982-Interferon-gamma,
pubmed-meshheading:20300982-Intestine, Large,
pubmed-meshheading:20300982-Killer Cells, Natural,
pubmed-meshheading:20300982-Liver,
pubmed-meshheading:20300982-Lymphocyte Culture Test, Mixed,
pubmed-meshheading:20300982-Major Histocompatibility Complex,
pubmed-meshheading:20300982-Mice,
pubmed-meshheading:20300982-Mice, Inbred C3H,
pubmed-meshheading:20300982-Mice, Inbred C57BL,
pubmed-meshheading:20300982-Mice, Inbred DBA,
pubmed-meshheading:20300982-Receptors, CXCR3,
pubmed-meshheading:20300982-Spleen
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| pubmed:year |
2010
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| pubmed:articleTitle |
Separation of antileukemic effects from graft-versus-host disease in MHC-haploidentical murine bone marrow transplantation: participation of host immune cells.
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| pubmed:affiliation |
Division of Hematology, Department of Internal Medicine, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan.
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| pubmed:publicationType |
Journal Article
|