| pubmed-article:2027751 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:2027751 | lifeskim:mentions | umls-concept:C1330957 | lld:lifeskim |
| pubmed-article:2027751 | lifeskim:mentions | umls-concept:C0023745 | lld:lifeskim |
| pubmed-article:2027751 | lifeskim:mentions | umls-concept:C0220781 | lld:lifeskim |
| pubmed-article:2027751 | lifeskim:mentions | umls-concept:C1883254 | lld:lifeskim |
| pubmed-article:2027751 | lifeskim:mentions | umls-concept:C0596311 | lld:lifeskim |
| pubmed-article:2027751 | lifeskim:mentions | umls-concept:C0332256 | lld:lifeskim |
| pubmed-article:2027751 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:2027751 | pubmed:dateCreated | 1991-6-11 | lld:pubmed |
| pubmed-article:2027751 | pubmed:abstractText | A self complementary oligodeoxynucleotide dodecamer containing an achiral bridged 5'-phosphorothioate linkage 3'-O-P-S-5' has been prepared using the solid phase phosphoramidite procedure. For the incorporation of the phosphorothioate link we have used a 5'-(S-trityl)-mercapto-5'-deoxythymidine-3'-phosphoramidite. After coupling this building block the S-trityl group was removed by silver ions. The free thiol moiety was then coupled with a standard phosphoramidite in the presence of tetrazole. After oxidation of the 5'-phosphorothioite with iodine/water the synthesis was continued with standard building blocks up to the desired dodecamer. This backbone modified dodecamer can be cleaved selectively and quantitatively at the P-S bond by silver or mercuric ions under very mild conditions. | lld:pubmed |
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| pubmed-article:2027751 | pubmed:language | eng | lld:pubmed |
| pubmed-article:2027751 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:2027751 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:2027751 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:2027751 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:2027751 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:2027751 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:2027751 | pubmed:author | pubmed-author:MaiKK | lld:pubmed |
| pubmed-article:2027751 | pubmed:author | pubmed-author:EngelsJ WJW | lld:pubmed |
| pubmed-article:2027751 | pubmed:author | pubmed-author:LükingSS | lld:pubmed |
| pubmed-article:2027751 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:2027751 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:2027751 | pubmed:volume | 19 | lld:pubmed |
| pubmed-article:2027751 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:2027751 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:2027751 | pubmed:pagination | 1437-41 | lld:pubmed |
| pubmed-article:2027751 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:2027751 | pubmed:meshHeading | pubmed-meshheading:2027751-... | lld:pubmed |
| pubmed-article:2027751 | pubmed:meshHeading | pubmed-meshheading:2027751-... | lld:pubmed |
| pubmed-article:2027751 | pubmed:meshHeading | pubmed-meshheading:2027751-... | lld:pubmed |
| pubmed-article:2027751 | pubmed:meshHeading | pubmed-meshheading:2027751-... | lld:pubmed |
| pubmed-article:2027751 | pubmed:meshHeading | pubmed-meshheading:2027751-... | lld:pubmed |
| pubmed-article:2027751 | pubmed:meshHeading | pubmed-meshheading:2027751-... | lld:pubmed |
| pubmed-article:2027751 | pubmed:meshHeading | pubmed-meshheading:2027751-... | lld:pubmed |
| pubmed-article:2027751 | pubmed:meshHeading | pubmed-meshheading:2027751-... | lld:pubmed |
| pubmed-article:2027751 | pubmed:year | 1991 | lld:pubmed |
| pubmed-article:2027751 | pubmed:articleTitle | Synthesis and selective cleavage of an oligodeoxynucleotide containing a bridged internucleotide 5'-phosphorothioate linkage. | lld:pubmed |
| pubmed-article:2027751 | pubmed:affiliation | Institut für Organische Chemie, Johann Wolfgang Goethe-Universität Frankfurt, FRG. | lld:pubmed |
| pubmed-article:2027751 | pubmed:publicationType | Journal Article | lld:pubmed |
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