Linked Life Data

20236711

Source:http://linkedlifedata.com/resource/pubmed/id/20236711

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-5-21
pubmed:abstractText
Despite frequent detection of ibuprofen in aquatic environments, the hazards associated with long-term exposure to ibuprofen have seldom been investigated. Ibuprofen is suspected of influencing sex steroid hormones through steroidogenic pathways in both vertebrates and invertebrates. In this study, the effect of ibuprofen on sex hormone balance and the associated mechanisms was investigated in vitro by use of H295R cells. We also conducted chronic toxicity tests using freshwater fish, Oryzias latipes, and two freshwater cladocerans, Daphnia magna and Moina macrocopa, for up to 144 and 21d of exposure, respectively. Ibuprofen exposure increased 17beta-estradiol (E2) production and aromatase activity in H295R cells. Testosterone (T) production decreased in a dose-dependent manner. For D. magna, the 48 h immobilization EC50 was 51.4 mg/L and the 21 d reproduction NOEC was <1.23 mg/L; for M. macrocopa, the 48 h immobilization EC50 was 72.6 mg/L and the 7d reproduction NOEC was 25mg/L. For O. latipes, 120 d survival NOEC was 0.0001 mg/L. In addition, ibuprofen affected several endpoints related to reproduction of the fish, including induction of vitellogenin in male fish, fewer broods per pair, and more eggs per brood. Parental exposure to as low as 0.0001 mg/L ibuprofen delayed hatching of eggs even when they were transferred to and cultured in clean water. Delayed hatching is environmentally relevant because this may increase the risk of being predated. For O. latipes, the acute-to-chronic ratio of ibuprofen was estimated to be greater than 1000. Overall, relatively high acute-to-chronic ratio and observation of reproduction damage in medaka fish at environmentally relevant ranges of ibuprofen warrant the need for further studies to elucidate potential ecological consequences of ibuprofen contamination in the aquatic environment.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
1879-1514
pubmed:author
pubmed:copyrightInfo
Copyright 2010 Elsevier B.V. All rights reserved.
pubmed:issnType
Electronic
pubmed:day
1
pubmed:volume
98
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
256-64
pubmed:meshHeading
pubmed-meshheading:20236711-Adrenocortical Carcinoma, pubmed-meshheading:20236711-Animals, pubmed-meshheading:20236711-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:20236711-Aromatase, pubmed-meshheading:20236711-Cell Line, Tumor, pubmed-meshheading:20236711-Cladocera, pubmed-meshheading:20236711-Daphnia, pubmed-meshheading:20236711-Dose-Response Relationship, Drug, pubmed-meshheading:20236711-Endocrine Disruptors, pubmed-meshheading:20236711-Estradiol, pubmed-meshheading:20236711-Fresh Water, pubmed-meshheading:20236711-Humans, pubmed-meshheading:20236711-Ibuprofen, pubmed-meshheading:20236711-Oryzias, pubmed-meshheading:20236711-Testosterone, pubmed-meshheading:20236711-Time Factors, pubmed-meshheading:20236711-Toxicity Tests, pubmed-meshheading:20236711-Water Pollutants, Chemical
pubmed:year
2010
pubmed:articleTitle
Endocrine disruption and consequences of chronic exposure to ibuprofen in Japanese medaka (Oryzias latipes) and freshwater cladocerans Daphnia magna and Moina macrocopa.
pubmed:affiliation
School of Public Health, Seoul National University, 28 Yunkeon, Chongro, Seoul 110-799, Republic of Korea.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't