| pubmed-article:20235331 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:20235331 | lifeskim:mentions | umls-concept:C0019196 | lld:lifeskim |
| pubmed-article:20235331 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:20235331 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:20235331 | lifeskim:mentions | umls-concept:C0524910 | lld:lifeskim |
| pubmed-article:20235331 | lifeskim:mentions | umls-concept:C0017431 | lld:lifeskim |
| pubmed-article:20235331 | lifeskim:mentions | umls-concept:C0201950 | lld:lifeskim |
| pubmed-article:20235331 | lifeskim:mentions | umls-concept:C0205251 | lld:lifeskim |
| pubmed-article:20235331 | lifeskim:mentions | umls-concept:C0428466 | lld:lifeskim |
| pubmed-article:20235331 | lifeskim:mentions | umls-concept:C0065055 | lld:lifeskim |
| pubmed-article:20235331 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:20235331 | pubmed:dateCreated | 2010-5-31 | lld:pubmed |
| pubmed-article:20235331 | pubmed:abstractText | Recently, genetic polymorphisms occurring in the interferon (IFN)-lambda gene region were associated with response to IFN-based treatment of hepatitis C infection. Both infection with the hepatitis C virus and IFN therapy are associated with decreased serum cholesterol and high cholesterol has been associated with increased likelihood to respond to IFN. We sought to determine if the IFN-lambda gene variant was also associated with serum lipid levels in chronic hepatitis C patients. We compared genotypes of the rs12979860 polymorphism, located proximal to the IL28 gene, with serum lipid and apolipoprotein levels in 746 subjects with chronic hepatitis C virus infection, not currently undergoing treatment, using multivariable analysis of variance. Levels of total cholesterol (P = 6.0 x 10(-4)), apolipoprotein B (P = 1.3 x 10(-6)) and low-density lipoprotein (LDL) cholesterol (P = 8.9 x 10(-10)) were significantly higher in subjects carrying the rs12979860 CC responder genotype compared with those with the CT or TT genotype. Levels of triglycerides (P = 0.03), apolipoprotein A-I (P = 0.06), and apolipoprotein E (P = 0.01) were slightly lower in the rs12979860 CC genotype group, whereas levels of high-density lipoprotein cholesterol (P = 0.78) and apolipoprotein C-III (P = 0.74) did not vary by rs12979860 genotype. CONCLUSION: Our results suggest that low levels of LDL cholesterol in chronic hepatitis C patients may be a marker of host endogenous IFN response to hepatitis C and that subjects with the rs12979860 CC responder genotype may have a lower endogenous IFN response to the virus. | lld:pubmed |
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| pubmed-article:20235331 | pubmed:language | eng | lld:pubmed |
| pubmed-article:20235331 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:20235331 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:20235331 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:20235331 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:20235331 | pubmed:issn | 1527-3350 | lld:pubmed |
| pubmed-article:20235331 | pubmed:author | pubmed-author:TillmannHans... | lld:pubmed |
| pubmed-article:20235331 | pubmed:author | pubmed-author:McHutchisonJo... | lld:pubmed |
| pubmed-article:20235331 | pubmed:author | pubmed-author:PatelKeyurK | lld:pubmed |
| pubmed-article:20235331 | pubmed:author | pubmed-author:MuirAndrew... | lld:pubmed |
| pubmed-article:20235331 | pubmed:author | pubmed-author:GuytonJohn... | lld:pubmed |
| pubmed-article:20235331 | pubmed:author | pubmed-author:ThompsonAlexa... | lld:pubmed |
| pubmed-article:20235331 | pubmed:author | pubmed-author:GardnerStephe... | lld:pubmed |
| pubmed-article:20235331 | pubmed:author | pubmed-author:McCarthyJeane... | lld:pubmed |
| pubmed-article:20235331 | pubmed:author | pubmed-author:SuchindranSun... | lld:pubmed |
| pubmed-article:20235331 | pubmed:author | pubmed-author:LaoXiang... | lld:pubmed |
| pubmed-article:20235331 | pubmed:author | pubmed-author:RowellJennife... | lld:pubmed |
| pubmed-article:20235331 | pubmed:author | pubmed-author:LiJosephine... | lld:pubmed |
| pubmed-article:20235331 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:20235331 | pubmed:volume | 51 | lld:pubmed |
| pubmed-article:20235331 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:20235331 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:20235331 | pubmed:pagination | 1904-11 | lld:pubmed |
| pubmed-article:20235331 | pubmed:dateRevised | 2011-7-28 | lld:pubmed |
| pubmed-article:20235331 | pubmed:meshHeading | pubmed-meshheading:20235331... | lld:pubmed |
| pubmed-article:20235331 | pubmed:meshHeading | pubmed-meshheading:20235331... | lld:pubmed |
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| pubmed-article:20235331 | pubmed:meshHeading | pubmed-meshheading:20235331... | lld:pubmed |
| pubmed-article:20235331 | pubmed:meshHeading | pubmed-meshheading:20235331... | lld:pubmed |
| pubmed-article:20235331 | pubmed:meshHeading | pubmed-meshheading:20235331... | lld:pubmed |
| pubmed-article:20235331 | pubmed:year | 2010 | lld:pubmed |
| pubmed-article:20235331 | pubmed:articleTitle | Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection. | lld:pubmed |
| pubmed-article:20235331 | pubmed:affiliation | Institute for Genome Sciences and Policy, Durham, NC 27708, USA. | lld:pubmed |
