Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2010-5-31
pubmed:abstractText
Recently, genetic polymorphisms occurring in the interferon (IFN)-lambda gene region were associated with response to IFN-based treatment of hepatitis C infection. Both infection with the hepatitis C virus and IFN therapy are associated with decreased serum cholesterol and high cholesterol has been associated with increased likelihood to respond to IFN. We sought to determine if the IFN-lambda gene variant was also associated with serum lipid levels in chronic hepatitis C patients. We compared genotypes of the rs12979860 polymorphism, located proximal to the IL28 gene, with serum lipid and apolipoprotein levels in 746 subjects with chronic hepatitis C virus infection, not currently undergoing treatment, using multivariable analysis of variance. Levels of total cholesterol (P = 6.0 x 10(-4)), apolipoprotein B (P = 1.3 x 10(-6)) and low-density lipoprotein (LDL) cholesterol (P = 8.9 x 10(-10)) were significantly higher in subjects carrying the rs12979860 CC responder genotype compared with those with the CT or TT genotype. Levels of triglycerides (P = 0.03), apolipoprotein A-I (P = 0.06), and apolipoprotein E (P = 0.01) were slightly lower in the rs12979860 CC genotype group, whereas levels of high-density lipoprotein cholesterol (P = 0.78) and apolipoprotein C-III (P = 0.74) did not vary by rs12979860 genotype. CONCLUSION: Our results suggest that low levels of LDL cholesterol in chronic hepatitis C patients may be a marker of host endogenous IFN response to hepatitis C and that subjects with the rs12979860 CC responder genotype may have a lower endogenous IFN response to the virus.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-10084106, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-10535997, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-10787379, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-10886050, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-11103068, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-11297957, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-11322205, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-12072493, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-12646795, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-12809841, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-14668447, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-15139979, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-1525120, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-15761071, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-15845431, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-15887125, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-16364083, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-16404404, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-16425410, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-16476701, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-16734557, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-16871569, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-17105512, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-17126448, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-17156886, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-17410286, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-17498221, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-17625010, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-17784784, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-18467494, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-18955664, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-19139765, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-19392865, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-19749757, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-19749758, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-2445857, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-6174110, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-8389799, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-8528943, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-9032585, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-9185775, http://linkedlifedata.com/resource/pubmed/commentcorrection/20235331-9201435
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
1527-3350
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
51
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1904-11
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Interferon-lambda genotype and low serum low-density lipoprotein cholesterol levels in patients with chronic hepatitis C infection.
pubmed:affiliation
Institute for Genome Sciences and Policy, Durham, NC 27708, USA.
More...