Linked Life Data

20232847

Source:http://linkedlifedata.com/resource/pubmed/id/20232847

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2010-4-9
pubmed:abstractText
A serine/threonine-based chemoselective ligation method is described. It uses an O-salicylaldehyde ester at the C-terminus, reacting with N-terminal serine or threonine to realize peptide ligations. The utility of the O-salicylaldehyde ester enables the rapid coupling reaction and the production of an N,O-benzylidene acetal intermediate, which is readily converted into natural peptidic linkages (Xaa-Ser/Thr) at the ligation site.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1523-7052
pubmed:author
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1724-7
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Salicylaldehyde ester-induced chemoselective peptide ligations: enabling generation of natural peptidic linkages at the serine/threonine sites.
pubmed:affiliation
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, China. xuechenl@hku.hk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't