Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
|
pubmed:dateCreated |
1991-6-3
|
pubmed:abstractText |
Sixteen patients who had shown a good clinical response to cyclosporine therapy during a randomized 6-month double blind study comparing cyclosporine with D-penicillamine in active rheumatoid arthritis, had an opportunity to participate in an open study with cyclosporine. The initial daily dose of cyclosporine was 5 mg/kg. Before the planned maximal duration of 18 months, there were 6 premature discontinuations, 2 because of inefficacy, 2 because of side effects, and 2 for other reasons. During the study there was an improvement in all clinical variables. Even under the strict conditions of our trial there was an irreversible loss of about 15% of renal function. Suggestions are given to minimize the chance of nephrotoxicity.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0315-162X
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
18
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
19-23
|
pubmed:dateRevised |
2004-11-17
|
pubmed:meshHeading |
pubmed-meshheading:2023194-Adult,
pubmed-meshheading:2023194-Aged,
pubmed-meshheading:2023194-Arthritis, Rheumatoid,
pubmed-meshheading:2023194-Creatinine,
pubmed-meshheading:2023194-Cyclosporins,
pubmed-meshheading:2023194-Double-Blind Method,
pubmed-meshheading:2023194-Female,
pubmed-meshheading:2023194-Glomerular Filtration Rate,
pubmed-meshheading:2023194-Humans,
pubmed-meshheading:2023194-Male,
pubmed-meshheading:2023194-Middle Aged,
pubmed-meshheading:2023194-Penicillamine,
pubmed-meshheading:2023194-Renal Circulation,
pubmed-meshheading:2023194-Time Factors
|
pubmed:year |
1991
|
pubmed:articleTitle |
Longterm cyclosporine therapy in rheumatoid arthritis.
|
pubmed:affiliation |
Department of Rheumatology, Diakonessen Hospital, Eindhoven, The Netherlands.
|
pubmed:publicationType |
Journal Article,
Clinical Trial
|