Source:http://linkedlifedata.com/resource/pubmed/id/20231464
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
13
|
| pubmed:dateCreated |
2010-4-1
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| pubmed:abstractText |
Dendritic cells (DCs) are key components of the adaptive immune system contributing to initiation and regulation of T cell responses. T cells continuously scan DCs in lymphoid organs for the presence of foreign antigen. However, little is known about the functional consequences of these frequent T cell-DC interactions without cognate antigen. Here we demonstrate that these contacts in the absence of foreign antigen serve an important function, namely, induction of a basal activation level in T cells required for responsiveness to subsequent encounters with foreign antigens. This basal activation is provided by self-recognition of MHC molecules on DCs. Following DC depletion in mice, T cells became impaired in TCR signaling and immune synapse formation, and consequently were hyporesponsive to antigen. This process was reversible, as T cells quickly recovered when the number of DCs returned to a normal level. The extent of T cell reactivity correlated with the degree of DC depletion in lymphoid organs, suggesting that a full DC compartment guarantees optimal T cell responsiveness. These findings indicate that DCs are specialized cells that not only present foreign antigen, but also promote a "tonic" state in T cells for antigen responsiveness.
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| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Intercellular Signaling Peptides...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/heparin-binding EGF-like growth...
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
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| pubmed:issn |
1091-6490
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| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:day |
30
|
| pubmed:volume |
107
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
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| pubmed:pagination |
5931-6
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| pubmed:dateRevised |
2010-10-1
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| pubmed:meshHeading |
pubmed-meshheading:20231464-Animals,
pubmed-meshheading:20231464-Antigen Presentation,
pubmed-meshheading:20231464-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20231464-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20231464-Cell Count,
pubmed-meshheading:20231464-Cell Survival,
pubmed-meshheading:20231464-Dendritic Cells,
pubmed-meshheading:20231464-Humans,
pubmed-meshheading:20231464-Immunological Synapses,
pubmed-meshheading:20231464-Intercellular Signaling Peptides and Proteins,
pubmed-meshheading:20231464-Lymphocyte Activation,
pubmed-meshheading:20231464-Mice,
pubmed-meshheading:20231464-Mice, Congenic,
pubmed-meshheading:20231464-Mice, Inbred C57BL,
pubmed-meshheading:20231464-Mice, Transgenic,
pubmed-meshheading:20231464-Receptors, Antigen, T-Cell,
pubmed-meshheading:20231464-Recombinant Proteins,
pubmed-meshheading:20231464-Signal Transduction,
pubmed-meshheading:20231464-T-Lymphocytes,
pubmed-meshheading:20231464-Transplantation Chimera
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| pubmed:year |
2010
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| pubmed:articleTitle |
Dendritic cells control T cell tonic signaling required for responsiveness to foreign antigen.
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| pubmed:affiliation |
Division of Molecular Immunology, German Cancer Research Center, 69120 Heidelberg, Germany.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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