Linked Life Data

2022834

Source:http://linkedlifedata.com/resource/pubmed/id/2022834

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-6-6
pubmed:abstractText
The hypothesis that improved axonal regeneration occurs through nerve grafts when scarred tissue is removed and distal coaptation completed during a delayed, secondary operation was tested in a rabbit model. The ulnar nerve was used as a donor nerve graft to a final three-centimeter deficit of the contralateral median nerve. This was done either in one stage or in two stages, with resection of scar and coaptation at the distal site done ten weeks later. Evaluation included nerve conduction velocity, compound action potential area, muscle contraction force, muscle weight, and axon counts. Two-stage nerve grafts at 24 weeks were significantly inferior to one-stage grafts only in compound action potential area. Both nerve grafts showed significant improvement in function from twenty-four to sixty-two weeks as measured by nerve conduction velocity; two-staged grafts in addition showed a significant increase in compound action potential area and twitch contraction force. The data are inconclusive regarding the absolute superiority of two-stage versus one-stage grafting. Different timing for the second stage may be required.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0363-5023
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
262-8
pubmed:dateRevised
2009-6-8
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Comparison of one- and two-stage nerve grafting of the rabbit median nerve.
pubmed:affiliation
Christine M. Kleinert Institute for Hand and Micro Surgery, Louisville, Ky.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't