Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1978-2-23
pubmed:abstractText
An assessment was made of some of the basic parameters responsible for the modulation of adenylate cyclase activity in a bovine adrenocortical plasma-membrane preparation. When determined at 0.1 mM-ATP, basal adenylate cyclase activity increased with increasing MgCl2 concentrations, whereas in the presence of corticotropin activity was essentially maximal at 10mM-MgCl2; high concentrations (25mM) of MgCl2 inhibited adenylate cyclase activity determined in the presence of both corticotropin and GTP. At all MgCl2 concentrations, corticotropin and GTP activated the enzyme in a synergistic fashion. The magnitude of the stimulation of basal activity produced by corticotropin was a function of Mg2+ concentration, whereas that produced by GTP appeared largely independent of Mg2+ concentration. Adenylate cyclase activity in the bovine adrenal membrane was half-maximally stimulated by corticotropin concentrations in the range 0.3--1.0 nM. The concentration of corticotropin evoking half-maximum response was not significantly affected by raising the free Mg2+ concentration from 0.4 to 4.9 mM, nor by the presence of GTP. In the presence of GTP, high concentrations (over 1 micrometer) of corticotropin inhibited adenylate cyclase activity, although no inhibition was apparent in the absence of guanine nucleotide.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-1122028, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-1126950, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-1141221, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-1194261, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-12325369, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-14907713, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-164469, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-16742267, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-171590, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-177820, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-180000, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-188466, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-189224, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-4347679, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-4348344, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-4353624, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-4358641, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-4359333, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-4364028, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-4372220, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-4796, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-4827395, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-4926550, http://linkedlifedata.com/resource/pubmed/commentcorrection/202264-7447
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0264-6021
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
168
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
277-82
pubmed:dateRevised
2010-9-2
pubmed:meshHeading
pubmed:year
1977
pubmed:articleTitle
Modulation of the response of bovine adrenocortical adenylate cyclase to corticotropin.
pubmed:publicationType
Journal Article, In Vitro