Linked Life Data

2021499

Source:http://linkedlifedata.com/resource/pubmed/id/2021499

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-6-6
pubmed:abstractText
Methods are described for the syntheses of chloromethyl hydroxyalkylphenyl and benzyl ethers, and for the synthesis of bromomethyl phenyl ketone analogs. The hydroxy groups were protected as acetates. The halogenomethyl derivatives have been used for N-alkylation of 5-chloro-2(1H)-pyrimidinone. The acetyl groups in the products were removed by aminolysis or by enzymatic (pig liver esterase) hydrolysis. The hydroxy derivatives are chemically labile because of polymerization reactions. Adduct formation (1:1) with sodium hydrogensulfite improved the stability. The products are specific inhibitors of the cell cycle in the metaphase. In vitro data are given from screening in cultivated Chang liver cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0904-213X
pubmed:author
pubmed:issnType
Print
pubmed:volume
45
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
177-85
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Syntheses and studies of metaphase-arresting pyrimidinones.
pubmed:affiliation
Department of Chemistry, University of Oslo, Norway.
pubmed:publicationType
Journal Article