Linked Life Data

2019271

Source:http://linkedlifedata.com/resource/pubmed/id/2019271

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-5-24
pubmed:abstractText
The LH/CG receptor of MA-10 Leydig tumor cells can be down-regulated by LH/CG, mouse epidermal growth factor (mEGF), cAMP analogues and phorbol esters. In a recent publication we showed that the LH/CG-induced down regulation of the LH/CG receptor is primarily due to an increase in the rate of degradation of the receptor, and occurs with little or no change in the levels of LH/CG receptor mRNA. Although relatively unimportant for the LH/CG-induced down-regulation of the LH/CG receptor, we also found that LH/CG can in fact elicit a reduction in LH/CG receptor mRNA and that this reduction is mediated by cAMP. These findings raised the possibility that the ability of other compounds to down-regulate the LH/CG receptor may be accompanied by decreases in LH/CG receptor mRNA. In an attempt to answer this question, we examined the possibility that the mEGF- or phorbol ester-induced down regulation of the LH/CG receptor is due to changes in LH/CG receptor mRNA. The experiments presented herein show that this is indeed the case.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2651-3
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Epidermal growth factor and phorbol esters reduce the levels of the cognate mRNA for the LH/CG receptor.
pubmed:affiliation
Department of Physiology, University of Iowa College of Medicine, Iowa City 52242-1109.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't