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rdf:type |
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lifeskim:mentions |
umls-concept:C0013227,
umls-concept:C0030685,
umls-concept:C0033262,
umls-concept:C0220781,
umls-concept:C0391871,
umls-concept:C0599894,
umls-concept:C0678594,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1521840,
umls-concept:C1883254,
umls-concept:C1963578
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pubmed:issue |
7
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pubmed:dateCreated |
2010-3-26
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pubmed:abstractText |
Preparation of a novel c(RGDyK) targeted SN38 prodrug incorporating an indolequinone structure for bioreductively triggered drug release is described. This design yields a prodrug that targets surface molecules on tumor cells (alpha(v)beta(3) integrins) and releases drug under bioreductive conditions. There are three moieties in the prodrug design, namely a therapeutic drug SN38, an indolequinone structure serving as a drug releasing trigger, and an alpha(v)beta(3) integrin targeting peptide c(RGDyK). Preliminary studies showed that SN38 is released in the presence of a bioreductive enzyme (DT-diaphorase).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-10514277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-11230497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-12007566,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-12139465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-12635171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-12825198,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-15170446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-16182400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-1714284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-1718779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-18939816,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-2296038,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-7543770,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-7620214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-8051114,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-8691448,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-8885327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20192275-9240349
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
1523-7052
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1384-7
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pubmed:dateRevised |
2011-7-27
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pubmed:meshHeading |
pubmed-meshheading:20192275-Camptothecin,
pubmed-meshheading:20192275-Cell Proliferation,
pubmed-meshheading:20192275-Dose-Response Relationship, Drug,
pubmed-meshheading:20192275-Drug Screening Assays, Antitumor,
pubmed-meshheading:20192275-Female,
pubmed-meshheading:20192275-Humans,
pubmed-meshheading:20192275-Indolequinones,
pubmed-meshheading:20192275-Integrin alphaVbeta3,
pubmed-meshheading:20192275-KB Cells,
pubmed-meshheading:20192275-Molecular Structure,
pubmed-meshheading:20192275-NAD(P)H Dehydrogenase (Quinone),
pubmed-meshheading:20192275-Oxidation-Reduction,
pubmed-meshheading:20192275-Peptides, Cyclic,
pubmed-meshheading:20192275-Prodrugs,
pubmed-meshheading:20192275-Structure-Activity Relationship,
pubmed-meshheading:20192275-Time Factors,
pubmed-meshheading:20192275-Uterine Cervical Neoplasms
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pubmed:year |
2010
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pubmed:articleTitle |
The synthesis of a c(RGDyK) targeted SN38 prodrug with an indolequinone structure for bioreductive drug release.
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pubmed:affiliation |
Michigan Nanotechnology Institute for Medicine and Biological Sciences, University of Michigan, Ann Arbor, Michigan 48109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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