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rdf:type |
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lifeskim:mentions |
umls-concept:C0008976,
umls-concept:C0013227,
umls-concept:C0030705,
umls-concept:C0087111,
umls-concept:C0205164,
umls-concept:C0281351,
umls-concept:C0392747,
umls-concept:C0679199,
umls-concept:C1275278,
umls-concept:C1707689,
umls-concept:C1720655,
umls-concept:C1947974,
umls-concept:C2699007,
umls-concept:C2700455
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pubmed:dateCreated |
2010-3-15
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pubmed:databankReference |
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pubmed:abstractText |
In major depressive disorder (MDD), the traditional belief of a delayed onset of antidepressants' effects has lead to the concept of current guidelines that treatment durations should be between 3-8 weeks before medication change in case of insufficient outcome. Post hoc analyses of clinical trials, however, have shown that improvement usually occurs within the first 10-14 days of treatment and that such early improvement (Hamilton Depression Rating Scale [HAMD] decrease >or=20%) has a substantial predictive value for final treatment outcome. Even more important, non-improvement (HAMD decrease <20%) after 14 days of treatment was found to be highly predictive for a poor final treatment outcome.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-10964858,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-12000207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-12363118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-12716243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-14627997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-14728109,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-15367045,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-15551191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-15704999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-15868067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-16172440,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-16415707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-16554525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-17088502,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-17132052,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-17194261,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-17388703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-17455102,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-17592920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-17854243,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-18199864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-18221624,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-18308513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-18348888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-19185342,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-19254516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-1929776,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-19428118,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-3548638,
http://linkedlifedata.com/resource/pubmed/commentcorrection/20187947-6080235
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1745-6215
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pubmed:author |
pubmed-author:BrausDieter FDF,
pubmed-author:DahmenNorbertN,
pubmed-author:EMC Study Group,
pubmed-author:GorbauchThorstenT,
pubmed-author:GorbulevStanislavS,
pubmed-author:HiemkeChristophC,
pubmed-author:KronfeldKaiK,
pubmed-author:LiebKlausK,
pubmed-author:RöschkeJoachimJ,
pubmed-author:Seibert-GrafeMonikaM,
pubmed-author:Tadi?AndréA,
pubmed-author:WachtlinDanielD,
pubmed-author:van CalkerDietrichD
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pubmed:issnType |
Electronic
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
21
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pubmed:dateRevised |
2010-9-30
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pubmed:meshHeading |
pubmed-meshheading:20187947-Antidepressive Agents,
pubmed-meshheading:20187947-Depressive Disorder, Major,
pubmed-meshheading:20187947-Drug Administration Schedule,
pubmed-meshheading:20187947-Germany,
pubmed-meshheading:20187947-Guideline Adherence,
pubmed-meshheading:20187947-Humans,
pubmed-meshheading:20187947-Practice Guidelines as Topic,
pubmed-meshheading:20187947-Prospective Studies,
pubmed-meshheading:20187947-Psychiatric Status Rating Scales,
pubmed-meshheading:20187947-Research Design,
pubmed-meshheading:20187947-Treatment Failure,
pubmed-meshheading:20187947-Treatment Outcome
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pubmed:year |
2010
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pubmed:articleTitle |
Rationale and design of the randomised clinical trial comparing early medication change (EMC) strategy with treatment as usual (TAU) in patients with major depressive disorder--the EMC trial.
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pubmed:affiliation |
Department of Psychiatry and Psychotherapy, University Medical Centre Mainz, Germany. tadic@uni-mainz.de
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pubmed:publicationType |
Journal Article,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study,
Clinical Trial, Phase IV
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