Linked Life Data

2018358

Source:http://linkedlifedata.com/resource/pubmed/id/2018358

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1991-5-23
pubmed:abstractText
The antimetastatic effect of calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) was examined in an experimental model of lung metastasis induced by Lewis lung carcinomas (3LL) in C57BL/6crSlc mice. 3LL cells were implanted into the footpad of the mice. Ten days later, the implanted primary tumors were surgically removed. Injection of W-7 i.v. after removal of the implanted primary tumor caused the greatest inhibition of development of lung metastases. The number of peritoneal macrophages, total cells and macrophages in the lung increased in mice treated with W-7. Binding of the third component of complement (C3) cleavage products (C3b) to the C3 receptor on peritoneal macrophages after i.v. injection of W-7 were enhanced, as shown by the fluorescent antibody technique. Lung metastases were inhibited by i.v. injection of peritoneal macrophages activated with W-7. A possible mechanism of inhibition of lung metastases by treatment with W-7 could be interpreted as due to C3 activation and macrophage activation. These findings raise the possibility that W-7 may have clinical value in the prevention of cancer metastasis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
249-52
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:articleTitle
Inhibition of lung metastasis by a calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), in mice bearing Lewis lung carcinoma.
pubmed:affiliation
Department of Pharmacology, Mie University School of Medicine, Japan.
pubmed:publicationType
Journal Article