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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2010-2-25
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pubmed:abstractText |
Little is known about the longitudinal effects of smoking cessation on sputum inflammatory cells. We aimed to investigate the changes in sputum inflammatory cells and T-lymphocyte subpopulations after 6 and 12 months smoking cessation. Induced sputum was obtained from 68 healthy smokers before and after 6 months (n = 21) and 1 year (n = 14) smoking cessation and from ten healthy never-smokers. Inflammatory cells were identified by morphology and T-lymphocyte subpopulations by flow cytometry. Sputum macrophages were decreased after 12 months of smoking cessation in comparison to baseline, while neutrophils increased. Moreover, CD8+ T-cells were decreased in smokers before smoking cessation compared to never-smokers and increased in smokers after 6 months of smoking cessation in comparison to baseline; result that was maintained after 1 year of smoking cessation. These novel findings indicate that smoking cessation can equilibrate certain inflammatory cells of smokers with those of nonsmokers, within 6 months of smoking cessation.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:issn |
1466-1861
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
2009
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
812102
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pubmed:dateRevised |
2010-9-28
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pubmed:meshHeading |
pubmed-meshheading:20182552-Adult,
pubmed-meshheading:20182552-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:20182552-CD4-Positive T-Lymphocytes,
pubmed-meshheading:20182552-CD8-Positive T-Lymphocytes,
pubmed-meshheading:20182552-Female,
pubmed-meshheading:20182552-Humans,
pubmed-meshheading:20182552-Male,
pubmed-meshheading:20182552-Middle Aged,
pubmed-meshheading:20182552-Risk Factors,
pubmed-meshheading:20182552-Smoking Cessation,
pubmed-meshheading:20182552-Sputum,
pubmed-meshheading:20182552-T-Lymphocyte Subsets
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pubmed:year |
2009
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pubmed:articleTitle |
Maintained smoking cessation for 6 months equilibrates the percentage of sputum CD8+ lymphocyte cells with that of nonsmokers.
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pubmed:affiliation |
Department of Thoracic Medicine, University General Hospital, Medical School of the University of Crete, 71110 Heraklion, Greece. izolthi@yahoo.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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