Linked Life Data

20174854

Source:http://linkedlifedata.com/resource/pubmed/id/20174854

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-8-23
pubmed:abstractText
The objective of this study was to evaluate, in a series of 43 pediatric high-grade gliomas (21 anaplastic astrocytoma WHO grade III and 22 glioblastoma WHO grade IV), the prognostic value of histological grading and expression of p53 and YKL-40. Moreover, mutational screening for TP53 and IDH1 was performed in 27 of 43 cases. The prognostic stratification for histological grading showed no difference in overall (OS) and progression-free survival (PFS) between glioblastomas and anaplastic astrocytomas. Overexpression of YKL40 was detected in 25 of 43 (58%) cases, but YKL-40 expression was not prognostic in terms of OS and PFS. p53 protein expression was observed in 13 of 43 (31%) cases but was not prognostic. TP53 mutations were detected in five of 27 (18%) cases (four glioblastomas and one anaplastic astrocytoma). Patients with TP53 mutation had a shorter median OS (9 months) and PFS (8 months) than those without mutations (OS, 17 months; PFS, 16 months), although this trend did not reach statistical significance (p = 0.07). IDH1 mutations were not detected in any of the cases analyzed. Our results suggest that in pediatric high-grade gliomas: (i) histological grading does not have strong prognostic significance, (ii) YKL-40 overexpression is less frequent than adult high-grade gliomas and does not correlate with a more aggressive behavior, (iii) TP53 mutations but not p53 expression may correlate with a more aggressive behavior, and (iv) IDH1 mutations are absent. These observations support the concept that, despite identical histological features, the biology of high-grade gliomas in children differs from that in adults, and therefore different prognostic factors are needed.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1573-7373
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
99
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
209-15
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed-meshheading:20174854-Adipokines, pubmed-meshheading:20174854-Adolescent, pubmed-meshheading:20174854-Adult, pubmed-meshheading:20174854-Astrocytoma, pubmed-meshheading:20174854-Brain Neoplasms, pubmed-meshheading:20174854-Child, pubmed-meshheading:20174854-Child, Preschool, pubmed-meshheading:20174854-DNA, Neoplasm, pubmed-meshheading:20174854-Female, pubmed-meshheading:20174854-Glycoproteins, pubmed-meshheading:20174854-Humans, pubmed-meshheading:20174854-Immunoenzyme Techniques, pubmed-meshheading:20174854-Infant, pubmed-meshheading:20174854-Infant, Newborn, pubmed-meshheading:20174854-Isocitrate Dehydrogenase, pubmed-meshheading:20174854-Lectins, pubmed-meshheading:20174854-Male, pubmed-meshheading:20174854-Mutation, pubmed-meshheading:20174854-Neoplasm Staging, pubmed-meshheading:20174854-Polymerase Chain Reaction, pubmed-meshheading:20174854-Prognosis, pubmed-meshheading:20174854-Tumor Suppressor Protein p53, pubmed-meshheading:20174854-Young Adult
pubmed:year
2010
pubmed:articleTitle
Prognostic significance of histological grading, p53 status, YKL-40 expression, and IDH1 mutations in pediatric high-grade gliomas.
pubmed:affiliation
Department of Experimental Medicine, Sapienza University, Rome, Italy. felice.giangaspero@uniroma1.it
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't