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PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2010-2-23
pubmed:abstractText
Neural responses are typically characterized by computing the mean firing rate, but response variability can exist across trials. Many studies have examined the effect of a stimulus on the mean response, but few have examined the effect on response variability. We measured neural variability in 13 extracellularly recorded datasets and one intracellularly recorded dataset from seven areas spanning the four cortical lobes in monkeys and cats. In every case, stimulus onset caused a decline in neural variability. This occurred even when the stimulus produced little change in mean firing rate. The variability decline was observed in membrane potential recordings, in the spiking of individual neurons and in correlated spiking variability measured with implanted 96-electrode arrays. The variability decline was observed for all stimuli tested, regardless of whether the animal was awake, behaving or anaesthetized. This widespread variability decline suggests a rather general property of cortex, that its state is stabilized by an input.
pubmed:grant
http://linkedlifedata.com/resource/pubmed/grant/, http://linkedlifedata.com/resource/pubmed/grant/1 EY13138-01, http://linkedlifedata.com/resource/pubmed/grant/1DP1OD006409, http://linkedlifedata.com/resource/pubmed/grant/DP1 OD006409-01, http://linkedlifedata.com/resource/pubmed/grant/EY014924, http://linkedlifedata.com/resource/pubmed/grant/EY015958, http://linkedlifedata.com/resource/pubmed/grant/EY016774, http://linkedlifedata.com/resource/pubmed/grant/EY018894, http://linkedlifedata.com/resource/pubmed/grant/EY019288, http://linkedlifedata.com/resource/pubmed/grant/EY02017, http://linkedlifedata.com/resource/pubmed/grant/EY04440, http://linkedlifedata.com/resource/pubmed/grant/EY05603, http://linkedlifedata.com/resource/pubmed/grant/F32 EY015958-03, http://linkedlifedata.com/resource/pubmed/grant/K99 EY018894-01A1, http://linkedlifedata.com/resource/pubmed/grant/R01 EY002017-26, http://linkedlifedata.com/resource/pubmed/grant/R01 EY003878-28, http://linkedlifedata.com/resource/pubmed/grant/R01 EY004440-27S1, http://linkedlifedata.com/resource/pubmed/grant/R01 EY004726-26, http://linkedlifedata.com/resource/pubmed/grant/R01 EY005603-23, http://linkedlifedata.com/resource/pubmed/grant/R01 EY012135-12, http://linkedlifedata.com/resource/pubmed/grant/R01 EY013138-01, http://linkedlifedata.com/resource/pubmed/grant/R01 EY016774-02, http://linkedlifedata.com/resource/pubmed/grant/R01 EY019288-01, http://linkedlifedata.com/resource/pubmed/grant/R01 EY019288-04, http://linkedlifedata.com/resource/pubmed/grant/R01 NS054283-05, http://linkedlifedata.com/resource/pubmed/grant/R01-NS054283, http://linkedlifedata.com/resource/pubmed/grant/R56 EY014924-06A1
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
1546-1726
pubmed:author
pubmed-author:ArmstrongKatherine MKM, pubmed-author:BradleyDavid CDC, pubmed-author:ChangSteve WSW, pubmed-author:ChurchlandMark MMM, pubmed-author:ClarkAndrew MAM, pubmed-author:CohenMarlene RMR, pubmed-author:CorradoGreg SGS, pubmed-author:CunninghamJohn PJP, pubmed-author:FersterDavidD, pubmed-author:FinnIan MIM, pubmed-author:HosseiniPaymonP, pubmed-author:KohnAdamA, pubmed-author:LisbergerStephen GSG, pubmed-author:MooreTirinT, pubmed-author:MovshonJ AnthonyJA, pubmed-author:NewsomeWilliam TWT, pubmed-author:PriebeNicholas JNJ, pubmed-author:RyuStephen ISI, pubmed-author:SahaniManeeshM, pubmed-author:SanthanamGopalG, pubmed-author:ScottBenjamin BBB, pubmed-author:ShenoyKrishna VKV, pubmed-author:SmithMatthew AMA, pubmed-author:SnyderLawrence HLH, pubmed-author:SugrueLeo PLP, pubmed-author:YuByron MBM
pubmed:issnType
Electronic
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
369-78
pubmed:dateRevised
2011-10-19
pubmed:meshHeading
pubmed-meshheading:20173745-Action Potentials, pubmed-meshheading:20173745-Anesthesia, pubmed-meshheading:20173745-Animals, pubmed-meshheading:20173745-Cats, pubmed-meshheading:20173745-Cerebral Cortex, pubmed-meshheading:20173745-Databases, Factual, pubmed-meshheading:20173745-Electrodes, Implanted, pubmed-meshheading:20173745-Factor Analysis, Statistical, pubmed-meshheading:20173745-Macaca fascicularis, pubmed-meshheading:20173745-Macaca mulatta, pubmed-meshheading:20173745-Macaca nemestrina, pubmed-meshheading:20173745-Membrane Potentials, pubmed-meshheading:20173745-Microelectrodes, pubmed-meshheading:20173745-Motor Activity, pubmed-meshheading:20173745-Neurons, pubmed-meshheading:20173745-Neuropsychological Tests, pubmed-meshheading:20173745-Time Factors, pubmed-meshheading:20173745-Video Recording, pubmed-meshheading:20173745-Visual Perception, pubmed-meshheading:20173745-Wakefulness
pubmed:year
2010
pubmed:articleTitle
Stimulus onset quenches neural variability: a widespread cortical phenomenon.
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