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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-5-17
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pubmed:abstractText |
The nature of the interaction between gamma-type endorphins and the HLA class I molecules was studied by immunoelectronmicroscopy. The HLA molecules were not involved in the actual binding of endorphin to the cell. In contrast, for the endocytosis of gamma-endorphin, co-internalization of the HLA class I molecules is essential. The internalization process starts with clustering of gamma-endorphin and HLA class I molecules in coated pits. Cells that do not carry HLA class I molecules (Daudi) or do not internalize HLA class I molecules (EBV-transformed B cells) bind but do not internalize gamma-endorphin. On the basis of these observations, we suggest that the MHC class I molecules may function as transport molecules. Whether it is a general phenomenon that non-immunological ligands use the HLA class I molecules to get into the cell and immunological ligands (viral proteins) to reach the cell surface, remains to be established.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-2417123,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-2422143,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-2881559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-2886920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-2902138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-3090548,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-3091379,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-3547409,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-3996431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-4029177,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-4121290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-6130851,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-6194571,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-6288727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-6297785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-6324346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/2015708-6363594
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
170-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2015708-Antibodies, Monoclonal,
pubmed-meshheading:2015708-Cell Line, Transformed,
pubmed-meshheading:2015708-Endocytosis,
pubmed-meshheading:2015708-Endorphins,
pubmed-meshheading:2015708-Histocompatibility Antigens Class I,
pubmed-meshheading:2015708-Humans,
pubmed-meshheading:2015708-Immunohistochemistry,
pubmed-meshheading:2015708-Lymphocyte Activation,
pubmed-meshheading:2015708-Lymphocytes,
pubmed-meshheading:2015708-Microscopy, Immunoelectron,
pubmed-meshheading:2015708-Peptide Fragments,
pubmed-meshheading:2015708-Phytohemagglutinins
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pubmed:year |
1991
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pubmed:articleTitle |
Internalization of MHC class I molecules is a prerequisite for endocytosis of endorphin by lymphocytes.
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pubmed:affiliation |
Department of Dermatology, University of Leiden, The Netherlands.
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pubmed:publicationType |
Journal Article
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