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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1991-5-23
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pubmed:abstractText |
1. Almitrine bismesylate displays wide inter-subject variation in peak plasma concentrations and can induce peripheral polyneuropathy. 2. The phenotyped volunteer panel approach was used to examine whether almitrine oxidation displayed a genetic polymorphism of the debrisoquine/sparteine type. 3. There was no difference between poor and extensive metabolisers of debrisoquine with respect to the pharmacokinetics and metabolism of almitrine.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0306-5251
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
73-6
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:2015173-Adult,
pubmed-meshheading:2015173-Almitrine,
pubmed-meshheading:2015173-Chromatography, High Pressure Liquid,
pubmed-meshheading:2015173-Debrisoquin,
pubmed-meshheading:2015173-Female,
pubmed-meshheading:2015173-Humans,
pubmed-meshheading:2015173-Male,
pubmed-meshheading:2015173-Oxidation-Reduction,
pubmed-meshheading:2015173-Phenotype,
pubmed-meshheading:2015173-Polymorphism, Genetic,
pubmed-meshheading:2015173-Sparteine
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pubmed:year |
1991
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pubmed:articleTitle |
Metabolism of almitrine in extensive and poor metabolisers of debrisoquine/sparteine.
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pubmed:affiliation |
Unité de Pharmacologie Clinique, Hôpital Vésale, Montigny-le-Tilleul France.
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pubmed:publicationType |
Journal Article
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