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pubmed-article:20140850pubmed:abstractTextCytochrome P450 (CYP) 2J2 is a regulatory enzyme in the biosynthesis of biologically active CIS-epoxyeicosatrienoic acids (EETs). EETs have been suggested to modulate PPAR-gamma and PPAR-alpha transcription activity and play a role in stimulus-secretion coupling in pancreatic beta cells. Genetic abnormalities in the expression of CYP2J enzymes may play a role in the pathogenesis of type 2 diabetes mellitus (T2DM). Our objective was to investigate CYP2J2 G-50T polymorphism (rs890293) in association with insulin resistance markers and T2DM in a Chinese population.lld:pubmed
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pubmed-article:20140850pubmed:copyrightInfo(c) J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart, New York.lld:pubmed
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pubmed-article:20140850pubmed:articleTitleGenetic variation in the G-50T polymorphism of the cytochrome P450 epoxygenase CYP2J2 gene and the risk of younger onset type 2 diabetes among Chinese population: potential interaction with body mass index and family history.lld:pubmed
pubmed-article:20140850pubmed:affiliationDivision of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.lld:pubmed
pubmed-article:20140850pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:20140850pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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