Source:http://linkedlifedata.com/resource/pubmed/id/20140850
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
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| pubmed:dateCreated |
2010-6-9
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| pubmed:abstractText |
Cytochrome P450 (CYP) 2J2 is a regulatory enzyme in the biosynthesis of biologically active CIS-epoxyeicosatrienoic acids (EETs). EETs have been suggested to modulate PPAR-gamma and PPAR-alpha transcription activity and play a role in stimulus-secretion coupling in pancreatic beta cells. Genetic abnormalities in the expression of CYP2J enzymes may play a role in the pathogenesis of type 2 diabetes mellitus (T2DM). Our objective was to investigate CYP2J2 G-50T polymorphism (rs890293) in association with insulin resistance markers and T2DM in a Chinese population.
|
| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1439-3646
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| pubmed:author | |
| pubmed:copyrightInfo |
(c) J. A. Barth Verlag in Georg Thieme Verlag KG Stuttgart, New York.
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| pubmed:issnType |
Electronic
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| pubmed:volume |
118
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
346-52
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| pubmed:meshHeading |
pubmed-meshheading:20140850-Adolescent,
pubmed-meshheading:20140850-Adult,
pubmed-meshheading:20140850-Age of Onset,
pubmed-meshheading:20140850-Asian Continental Ancestry Group,
pubmed-meshheading:20140850-Body Mass Index,
pubmed-meshheading:20140850-China,
pubmed-meshheading:20140850-Cytochrome P-450 Enzyme System,
pubmed-meshheading:20140850-Diabetes Mellitus, Type 2,
pubmed-meshheading:20140850-Genetic Predisposition to Disease,
pubmed-meshheading:20140850-Humans,
pubmed-meshheading:20140850-Insulin Resistance,
pubmed-meshheading:20140850-Medical History Taking,
pubmed-meshheading:20140850-Obesity,
pubmed-meshheading:20140850-Oxygenases,
pubmed-meshheading:20140850-Polymorphism, Genetic,
pubmed-meshheading:20140850-Polymorphism, Restriction Fragment Length,
pubmed-meshheading:20140850-Polymorphism, Single Nucleotide,
pubmed-meshheading:20140850-Risk Assessment
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| pubmed:year |
2010
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| pubmed:articleTitle |
Genetic variation in the G-50T polymorphism of the cytochrome P450 epoxygenase CYP2J2 gene and the risk of younger onset type 2 diabetes among Chinese population: potential interaction with body mass index and family history.
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| pubmed:affiliation |
Division of Cardiology, Department of Internal Medicine, E-Da Hospital, I-Shou University, Kaohsiung, Taiwan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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