|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2010-2-5
|
|
pubmed:databankReference |
|
|
pubmed:abstractText |
To clarify the difference between gene expression signature of Epstein-Barr virus (EBV)-positive gammadelta T-cell lymphoproliferative disorders (LPD) and those in normal gammadelta T-cells, we set out to determine gene expression profiling using three gammadelta T-cell lines derived from patients with EBV-positive gammadelta T-cell LPD. Gene expression profiling using an Affymetrix Genechip revealed a unique gene expression pattern of NK cell receptors in gammadelta T-LPD cell lines. Genes encoding killer cell lectin-like receptors (KLR), such as KLRG1 and KLRB1 (CD161), were generally low in gammadelta T-LPD cell lines, while killer cell immunoglobulin-like receptors varied among cell lines. In addition, expression of CD161 surface antigen was found to be remarkably decreased in gammadelta T-LPD cell lines by flow cytometric analysis. We conclude that gammadelta T-cell expansion in EBV-positive gammadelta T-LPD is in part due to inappropriate expression of the NK cell receptors which related to impaired function cytotoxic T cells.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD,
http://linkedlifedata.com/resource/pubmed/chemical/ITGB3 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Integrin beta3,
http://linkedlifedata.com/resource/pubmed/chemical/KLRB1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/KLRG1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Lectins, C-Type,
http://linkedlifedata.com/resource/pubmed/chemical/NK Cell Lectin-Like Receptor...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell...,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Natural Killer Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Trans-Activators
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
1607-8454
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
15
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
43-7
|
|
pubmed:meshHeading |
pubmed-meshheading:20132662-Antigens, CD,
pubmed-meshheading:20132662-Cell Line, Tumor,
pubmed-meshheading:20132662-Epstein-Barr Virus Infections,
pubmed-meshheading:20132662-Flow Cytometry,
pubmed-meshheading:20132662-Gene Expression Profiling,
pubmed-meshheading:20132662-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:20132662-Herpesvirus 4, Human,
pubmed-meshheading:20132662-Humans,
pubmed-meshheading:20132662-Immunophenotyping,
pubmed-meshheading:20132662-Integrin beta3,
pubmed-meshheading:20132662-Lectins, C-Type,
pubmed-meshheading:20132662-Lymphoma, T-Cell,
pubmed-meshheading:20132662-Lymphoproliferative Disorders,
pubmed-meshheading:20132662-NK Cell Lectin-Like Receptor Subfamily B,
pubmed-meshheading:20132662-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:20132662-Receptors, Antigen, T-Cell, gamma-delta,
pubmed-meshheading:20132662-Receptors, Natural Killer Cell,
pubmed-meshheading:20132662-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:20132662-T-Lymphocyte Subsets,
pubmed-meshheading:20132662-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:20132662-Trans-Activators
|
|
pubmed:year |
2010
|
|
pubmed:articleTitle |
Aberrant expression of NK cell receptors in Epstein-Barr virus-positive gammadelta T-cell lymphoproliferative disorders.
|
|
pubmed:affiliation |
First Department of Internal Medicine, Tokyo Medical University, Japan.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
