Linked Life Data

20127284

Source:http://linkedlifedata.com/resource/pubmed/id/20127284

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2010-3-2
pubmed:abstractText
Vasomotor tone is regulated by a complex interplay of a variety of extrinsic neurohumoral and intrinsic factors. It is the endothelium that has a major influence on smooth muscle cell tone via the release of intrinsic vasoactive factors and is therefore an important regulator of vasomotor tone. Sphingolipids are an emerging class of lipid mediators with important physiological properties. In the last two decades it has not only become increasingly clear that sphingolipid signaling plays a pivotal role in immune function, but also its role in the vascular system is now becoming more recognized. In this mini-review we will highlight the possible cross-talk between sphingolipids and intrinsic vasoactive factors released by the endothelium. Via this cross-talk sphingolipids can orchestrate vasomotor tone and may therefore also be involved in the pathophysiology of disease states associated with endothelial dysfunction.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0219-1032
pubmed:author
pubmed:issnType
Electronic
pubmed:day
28
pubmed:volume
29
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-11
pubmed:dateRevised
2010-6-16
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Sphingolipids and the orchestration of endothelium-derived vasoactive factors: when endothelial function demands greasing.
pubmed:affiliation
Department Pharmacology and Pharmacotherapy, Academic Medical Center, Amsterdam, The Netherlands.
pubmed:publicationType
Journal Article, Review